Clinical efficacy of Methylprednisolone and the combined use of Lopinavir/Ritonavir with Arbidol in treatment of Coronavirus Disease 2019

https://doi.org/10.1002/jmv.26798

For all patients, there were no significant differences in the change of body temperature, the time for negative conversion and hospital stays whether LPV/r and ARB were jointly used or not. While for severe and critically severe patients, Methylprednisolone noticeably reduced the time for negative conversion. Meanwhile, the clinical efficacy was superior on patients receiving Methylprednisolone within 3 days upon admission, and the duration of hospital stays was much shorter when Methylprednisolone was given at a total dose of 0-400 mg than a higher dose of >400 mg if all patients received a similar dose per day. Nonetheless, no significant changes across hepatic, renal and myocardial function indexes were observed. LPV/r combined with ARB produced no noticeably better effect on COVID-19 patients relative to the single agent treatment. Additionally, Methylprednisolone was efficient in severe and critically severe cases, and superior efficacy could be realized upon its early, appropriate and short-term application.

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