Real-World Effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide Healthcare System in Peru

https://www.medrxiv.org/content/10.1101/2020.10.06.20208066v2

Among 5683 patients, 200 received HCT, 203 IVM, 1600 AZIT, 692 HCQ + AZIT, 358 IVM + AZIT, and 2630 received standard of care. The AZIT + HCQ group was associated with 84% higher all-cause mortality hazard rate compared to standard care (wHR=1.84, 95%CI 1.12-3.02). Consistently, AZIT + HCQ treatment was associated with deaths or ICU transfer ICU (wHR=1.49, 95%CI 1.01-2.19), and deaths or oxygen prescription (wHR=1.70, 95%CI 1.07-2.69). HCQ treatment was only associated with death or oxygen prescription (wHR=1.77, 95% CI 1.01-3.11), and IVM was only associated with death or ICU transfer (wHR=1.58, 95%CI 1.11-2.25). No effect was found for AZIT or AZIT + IVM. Conclusion: Our study reported no beneficial effects of hydroxychloroquine, ivermectin, azithromycin, or their combinations. The AZIT+HCQ treatment reported increased risk of all-cause mortality.

Tags: , ,