(27 April 2020) Glycyrrhizin – Phytopharmaceuticals- novel therapeutic interventions for COVID-19

Pharmacologic perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19

https://www.sciencedirect.com/science/article/pii/S0924857920301539?via%3Dihub

Glycyrrhizin, a triterpene saponine, is valuable for its various biological functions and pharmacology effects. This article discusses the therapeutic potential of glycyrrhizin for COVID-19 from the perspective of its pharmacological action including binding angiotensin converting enzyme II (ACE2), down-regulating proinflammatory cytokines, inhibiting the accumulation of intracellular ROS, inhibiting thrombin, inhibiting the hyperproduction of airway exudates, and inducing endogenous interferon.