The effects of favipiravir on hematological parameters of covid-19 patients.

https://doi.org/10.1590/1806-9282.66.S2.65

Sixty-two cases receiving favipiravir treatment for at least five days due to COVID-19 infection were evaluated retrospectively. The mean age of the patients receiving treatment with favipiravir was 63.7+/-12.3 years. Nasopharyngeal swab positivity was detected in 67.7%. The most common comorbid conditions detected in patients were hypertension in 25 cases (40.3%) and diabetes in 16 cases (25.8%). In the statistical analysis of the hematological parameters before and after treatment with favipiravir, WBC, PT-PTT-INR levels were found to be unaffected; the mean RBC was found to have decreased from 4.33 +/- 0.58 M/uL to 4.16 +/- 0.54 M/uL (p:0.003); the median hemoglobin level was found to have decreased from 12.3 g/dl to 11.9 g/dl (p:0.041); the hematocrit level decreased from 38.1% +/- 4.8 to 36.9% +/- 4.2 (p:0.026); the median neutrophil count decreased from 4.57 K/uL to 3.85 K/uL (p:0.001); the mean lymphocyte count increased from 1.22 +/- 0.53 K/uL to 1.84 +/- 1.19 K/uL (p:0.000); and the mean platelet count increased from 244.1 +/- 85.1 K/uL to 281.9 +/- 103.3 K/uL (p:0.005). We concluded that the pathological effect of treatment with favipiravir on the hematologic system was the suppression in the erythrocyte series, and there were no adverse effects in other hematologic parameters.

 

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