(13 May 2020) Lactoferrin-significantly interfere with SARSCoV-2 replication in vitro at 1 mg/mL

In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin

https://doi.org/10.1101/2020.05.13.093781

Using an antiviral assay based on quantitative reverse transcription-polymerase chain reaction (qRT-PCR), it was found that Bovine lactoferrin (bLf) reduced progeny virus yield by up to ~84,6% in African green monkey kidney epithelial cells (Vero E6) and ~68,6% in adenocarcinomic human alveolar basal epithelial cells (A549) at 1 mg/mL, a concentration previously shown to have low cytotoxicity. Therefore, these  preliminary data suggest that bLf has the potential to constitute a biochemical approach to fight the new coronavirus pandemic.