(10 Mar 2021) Remdesivir- no positive effect on clinical outcomes

In total, 1907 of 15,225 patients met our inclusion criteria. After PS matching, 74 patients were assigned to the remdesivir case group and 195 patients to the non-remdesivir control group. In a PS-matched cohort, fatality risk (12.2% vs 13.3%; P = 1.0); risk of IMV/ECMO (5.4% vs 4.6%; P = 0.757); length of intensive care unit stay (6 vs 6 days; P = 0.473) and length of IMV (13 vs 5 days; P = 0.509) were not different between the case and control groups. LoS in the case group was longer than in the control group (14 vs 11 days; P < 0.001). This study suggested that remdesivir may have no positive effect on clinical outcomes and reductions in invasive/non-invasive respiratory support for patients with COVID-19 in Japan.