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TitleA process for the selective synthesis of one enantiomer of venlafaxine via a novel approach
Knowhow is available forA novel approach towards total synthesis of (-)-venlafaxine with a short process for asymmetric synthesis of venlafaxine, wherein one enantiomer is obtained in improved yields and in high enantiomeric purity, circumventing the need for resolution
- Acute treatment of major depressive disorder, generalized anxiety disorder
Venlafaxine is one of the most prescribed nontricyclic antidepressants. It has a well documented efficacy and safety for clinical use, with a reduced or completely diminished cardiovascular or anticholinergic liability. Venlafaxine is marketed in racemic form, although both R & S enantiomers show different bio activities i.e. S-enantiomer is a selective serotonin reuptake inhibitor, while R enantiomer is more selective towards norepinephrine transporter. Also, it has either no or has little activity on a variety of neuroreceptors. This invention fills the need for a synthetic process for the asymmetric total synthesis of either R or S venlafaxine using environment friendly reagents and ambient reaction conditions in the most concise manner possible so as to minimize the reaction steps in its synthesis
Advantages- Use of cheap and easily available raw materials
- Use of cost effective and environmentally friendly reaction conditions
- Avoidance of expensive catalysts
- Avoidance of additional steps involving resolution of enantiomers
- Improved overall yields with Enantiomeric purity >99%
- Strategy of asymmetric synthesis can be extended to the synthesis of both enantiomers
- Derivatives of venlafaxine can be prepared in the same manner

Knowhow is listed under following categories

Knowhow from
Scientific/ engineering subject areas Chemical sciences & engineering
Investor interest categories Biotechnology/ Biomedical/ Health Technologies
Industries Pharmaceuticals, Bulk Drugs, Formulations ; Organic Chemicals, Fine Chemicals, Intermediates, Feedstocks
Customer categories and nature of business Businesses and other industries (B2B)
Technology readiness levels TRL B: Proof-of-concept demonstrated in lab scale

Year of development
Whether patents are part of this offering ?Yes

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Published Patents

Database reference

Database record number 20140509043408
Date of upload 9 / May / 2014
Date of update 15 / May / 2014
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20140509043408
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