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TitleA cost effective process for the preparation of phosphorous ligands and their precursors (valuable intermediates in organic synthesis)
Knowhow is available forA cost effective, one reactor synthesis process for aryl phosphonates/phosphinates/phosphine oxides which are important ligand useful in organic synthesis
SummaryAryl and hetero-aryl phosphorous compounds including phosphonates, phosphinites and phosphine oxides are valuable intermediates in organic synthesis and find applications in polymer synthesis, medicinal chemistry and nucleic acid chemistry.
Conventional process for synthesis of aryl phosphorous compounds requires expensive ligands. In addition these processes need to be carried out at high temperature, are time consuming and requires more than one reactor. CSIR-NCL has developed a cost effective process that overcomes these processes for the synthesis of aryl phosphorous compounds. This process is a one pot, transition metal free reaction and can be carried out at room temperature.
Advantages- Raw materials required for process are commercially available and inexpensive
- All successive chemical reactions are carried out in one reactor
- Process can be carried out at room temperature
- The process is useful in generating chiral phosphine oxides under mild conditions that can serve as precursors to obtain novel aryl-phosphine ligands useful in organic synthesis

Knowhow is listed under following categories

Knowhow from
Scientific/ engineering subject areas Chemical sciences & engineering
Investor interest categories Others
Industries Organic Chemicals, Fine Chemicals, Intermediates, Feedstocks
Customer categories and nature of business Businesses and other industries (B2B)
Technology readiness levels TRL C: Prototype developed and tested; technology demonstrated at pilot scale

Year of development
Whether patents are part of this offering ?Yes

Related documents:

Published Patents

Database reference

Database record number 20140423121322
Date of upload 23 / Apr / 2014
Date of update 23 / Apr / 2014
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20140423121322
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