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TitleA cost effective process for the synthesis of cleistenolide, its derivatives and analogs
Knowhow is available forA simple, cost effective process for the synthesis of natural product cleistenolide useful as antifungal and anti-tumor agent
SummaryCleistenolide is a natural substance derived from Cleistochlamys kirkii Oliver plant. It exhibits diverse array of biological activities such as activity against Staphylococcus aureus and Bacillus anthracis, as well antifungal activity against Candida albicans. Further it can be useful in treatment of wound infections, rheumatism, and tuberculosis.
Current processes for synthesis of cleistenolide involve chiral starting materials, which mandate the process protection strategies, special conditions, and reagents. Further, these processes do not result in high yield of final product.
To address this issue CSIR-NCL has developed simple, economical, short process for synthesis of racemic as well as chiral Cleistenolide and its derivatives and analogues.
Advantages- The process doesn’t require chiral starting materials, which renders process more cost effective
- This process results in high yield of final product such as lactone compounds and its analogs, derivatives, salts
- This is a shorter process and economically attractive
- Process requires minimal requirement of protecting groups for the synthesis

Knowhow is listed under following categories

Knowhow from
Scientific/ engineering subject areas Chemical sciences & engineering
Investor interest categories Others
Industries Organic Chemicals, Fine Chemicals, Intermediates, Feedstocks ; Pharmaceuticals, Bulk Drugs, Formulations
Customer categories and nature of business Businesses and other industries (B2B)
Technology readiness levels TRL C: Prototype developed and tested; technology demonstrated at pilot scale

Year of development
Whether patents are part of this offering ?Yes

Related documents:

Published Patents

Database reference

Database record number 20140423030244
Date of upload 23 / Apr / 2014
Date of update 23 / Apr / 2014
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20140423030244
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