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| Knowhow offering | |
| Title | New Chemical Entities (NCE) for treatment of malaria and CNS disorders |
| Knowhow is available for | New Chemical Entities (NCE) that may be employed as potential leads to prepare antimalarial drugs or treatment of Central Nervous System (CNS) disorders |
| Summary | NCL scientists have discovered NCEs (substituted pyridine based alkaloids) and an efficient, fully synthetic route for their synthesis. The NCEs have antimalarial activity and some analogues could be used to treat CNS disorders. The process has an overall yield of >65%. The reaction temperature is mild (~50 â°C). |
| Advantages | • Potential drug candidates (with high anti-malarial activity) for the treatment of plasmodium and potentially, CNS disorders • Efficient synthetic approach, with milder reaction conditions • Higher yields in the order of >65% for all the compounds |
| Knowhow is listed under following categories | |
| Knowhow from | CSIR-NCL, Pune |
| Scientific/ engineering subject areas | Chemical sciences & engineering ; Others |
| Investor interest categories | Others ; Others |
| Industries | Pharmaceuticals, Bulk Drugs, Formulations ; Others |
| Customer categories and nature of business | Businesses and other industries (B2B) ; Others |
| Technology readiness levels | TRL B: Proof-of-concept demonstrated in lab scale |
Year of development | 2011 |
| Whether patents are part of this offering ? | Yes |
| Related documents: | |
| Published Patents | |
| Publications |
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| Write- ups and marketing documents | |
| Database reference | |
| Database record number | 20131003043100 |
| Date of upload | 3 / Oct / 2013 |
| Date of update | 4 / Oct / 2013 |
| URL to site when communicating about this knowhow | http://nclinnovations.org/khdb/viewrecord.php?recordno=20131003043100 |
| Request for this technology | Click here for Request Form |
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