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TitleNew Chemical Entities (NCE) for treatment of malaria and CNS disorders
Knowhow is available forNew Chemical Entities (NCE) that may be employed as potential leads to prepare antimalarial drugs or treatment of Central Nervous System (CNS) disorders
SummaryNCL scientists have discovered NCEs (substituted pyridine based alkaloids) and an efficient, fully synthetic route for their synthesis. The NCEs have antimalarial activity and some analogues could be used to treat CNS disorders. The process has an overall yield of >65%. The reaction temperature is mild (~50 ⁰C).
Advantages• Potential drug candidates (with high anti-malarial activity) for the treatment of plasmodium and potentially, CNS disorders • Efficient synthetic approach, with milder reaction conditions • Higher yields in the order of >65% for all the compounds

Knowhow is listed under following categories

Knowhow from
Scientific/ engineering subject areas Chemical sciences & engineering ; Others
Investor interest categories Others ; Others
Industries Pharmaceuticals, Bulk Drugs, Formulations ; Others
Customer categories and nature of business Businesses and other industries (B2B) ; Others
Technology readiness levels TRL B: Proof-of-concept demonstrated in lab scale

Year of development
Whether patents are part of this offering ?Yes

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Published Patents
Write- ups and marketing documents

Database reference

Database record number 20131003043100
Date of upload 3 / Oct / 2013
Date of update 4 / Oct / 2013
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20131003043100
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