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TitleProcess for the continuous flow synthesis of beta-amino crotonate (for use in anti-hypertensive drugs)
Knowhow is available forA process for continuous flow synthesis of >99.98% pure beta- amino crotonates which are intermediates to calcium channel blockers (anti-hypertensive drugs)
SummaryA novel production process for beta-amino crotonate using a continuous mode reactor, with reduced reaction time, yet resulting in higher yield (>93%) and high-purity end-product (>99.98%). The process can be catalytic or catalysis- free : used to produce beta-amino crotonate and its analogues.
Advantages-Catalytic as well as catalysis-free, continuous process
-Beta amino crotonate yielded is of high purity-process provides better control on product profile
- Reduced reaction time
- Can be prepared from a variety of amines and beta keto esters

Knowhow is listed under following categories

Knowhow from
Scientific/ engineering subject areas Chemical sciences & engineering ; Others
Investor interest categories Others ; Others
Industries Pharmaceuticals, Bulk Drugs, Formulations ; Others
Customer categories and nature of business Businesses and other industries (B2B) ; Others
Technology readiness levels TRL B: Proof-of-concept demonstrated in lab scale

Year of development
Whether patents are part of this offering ?Yes

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Published Patents
Write- ups and marketing documents

Database reference

Database record number 20130930124812
Date of upload 30 / Sep / 2013
Date of update 19 / Feb / 2014
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20130930124812
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