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TitleNanogold-loaded sharp-edged carbon bullets as gene carriers
Knowhow is available forA process for making sharp edged carbon bullets, embedded with nanogold particles for gene delivery applications - with a capacity to carry more DNA cargo and perform efficient transformation when compared to conventional gene delivery methods
SummaryNCL scientists have developed a process for the preparation of carbon embedded nano gold particles with sharp edges which can be used as gene carriers. The bullets are sharp enough to penetrate hard material, with less damage (a comparatively lower force of 0.1-0.2 nN required for penetration) and can be delivered with a convenient delivery gun. Intracellular gold particles (biogenic) synthesized by a fungus in situ, embedded on a carbonaceous matrix.
Advantages• Preparation process is very simple and easy to implement • The carbon matrix forms 95% of the carrier reducing the amount of gold needed and the plasmid used per transformation • Advantages of usage of gold particles- High DNA packing density, better transformation efficiency, low nuclease degradation, being in nano scale, higher surface area is obtained- more gene cargo handled • Advantages of usage of carbon support- Inert and less damage causing- wound caused due to penetration healed faster, better piercing capacity, for example, can effectively pierce hard plant cell walls, less force required to penetrate the plasma membrane as compared to silver nano needles

Knowhow is listed under following categories

Knowhow from
Scientific/ engineering subject areas Life sciences/ biosciences & engineering ; Chemical sciences & engineering
Investor interest categories Materials Technology including Nanotechnology ; Biotechnology/ Biomedical/ Health Technologies
Industries Medical Biotechnology, Biomed Products, Medical Healthcare, Diagnostics ; Others
Customer categories and nature of business Businesses and other industries (B2B) ; Others
Technology readiness levels TRL B: Proof-of-concept demonstrated in lab scale

Year of development
Whether patents are part of this offering ?Yes

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Database reference

Database record number 20130930120815
Date of upload 30 / Sep / 2013
Date of update 4 / Oct / 2013
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20130930120815
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