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TitleProcess for Preparation of Copolymer-1-used in the treatment of multiple sclerosis
Knowhow is available forProcess for synthesis of CoPolymer1 and its pharmaceutically acceptable salts
SummaryA novel process using readily available raw materials, for the synthesis of Copolymer-1 and its pharmaceutically acceptable salts is described here. The process uses a polymer bound catalyst as an initiator (which requires 10X less catalyst concentration than conventional systems). The resulting polymer has a narrow molecular weight distribution, with m.wt can be tailored to be in the range of 8-19KDa. Copolymer-1 could be injected subcutaneously, intra-peritoneally, intravenously, intramuscularly for the treatment of multiple sclerosis.
Advantages• A simple, cost-effective process using easily available raw materials • Yields a product with high degree of purity (without requiring additional steps of separation, purification etc.) • Molecular weight can be tailored to be in the range of 8-19KDa (hence overcoming toxicity issues; m. wt of over 20 KDa are known to be toxic)- with excellent control over the m. wt distribution • High purity levels - almost no acid residues (less than 1% )

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Scientific/ engineering subject areas Chemical sciences & engineering ; Others
Investor interest categories Materials Technology including Nanotechnology ; Biotechnology/ Biomedical/ Health Technologies
Industries Pharmaceuticals, Bulk Drugs, Formulations ; Others
Customer categories and nature of business Businesses and other industries (B2B) ; Others
Technology readiness levels TRL B: Proof-of-concept demonstrated in lab scale

Year of development
Whether patents are part of this offering ?Yes

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Database reference

Database record number 20130929110322
Date of upload 30 / Sep / 2013
Date of update 4 / Oct / 2013
URL to site when communicating about this knowhow http://nclinnovations.org/khdb/viewrecord.php?recordno=20130929110322
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