{"id":943,"date":"2021-04-20T11:58:07","date_gmt":"2021-04-20T11:58:07","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=943"},"modified":"2021-04-20T11:58:07","modified_gmt":"2021-04-20T11:58:07","slug":"01-april-2021-peginterferon-lambda-1a-did-not-improve-the-symptoms","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/01-april-2021-peginterferon-lambda-1a-did-not-improve-the-symptoms\/","title":{"rendered":"(01 April 2021) Peginterferon Lambda-1a- did not improve the symptoms"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial<\/p>\n<p class=\"\">https:\/\/doi.org\/10.1038\/s41467-021-22177-1<\/p>\n<p class=\"\">NCT04331899- a randomized, single-blind, placebo-controlled trial in 120 outpatients with mild to moderate COVID-19 was conducted&nbsp; to determine whether a single, 180 mcg subcutaneous dose of Peginterferon Lambda-1a (Lambda) within 72 hours of diagnosis could shorten the duration of viral shedding (primary endpoint) or symptoms (secondary endpoint). In both the 60 patients receiving Lambda and 60 receiving placebo, the median time to cessation of viral shedding was 7 days (hazard ratio [HR] = 0.81; 95% confidence interval [CI] 0.56 to 1.19). Symptoms resolved in 8 and 9 days in Lambda and placebo, respectively, and symptom duration did not differ significantly between groups (HR 0.94; 95% CI 0.64 to 1.39). Both Lambda and placebo were well-tolerated, though liver transaminase elevations were more common in the Lambda vs. placebo arm (15\/60 vs 5\/60; p = 0.027). In this study, a single dose of subcutaneous Peginterferon Lambda-1a neither shortened the duration of SARS-CoV-2 viral shedding nor improved symptoms in outpatients with uncomplicated COVID-19<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial https:\/\/doi.org\/10.1038\/s41467-021-22177-1 NCT04331899- a randomized, single-blind, placebo-controlled trial in 120 outpatients with mild to moderate COVID-19 was conducted&nbsp; to determine whether a single, 180 mcg subcutaneous dose of&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/01-april-2021-peginterferon-lambda-1a-did-not-improve-the-symptoms\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(01 April 2021) Peginterferon Lambda-1a- did not improve the symptoms&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[6,4,30],"tags":[108],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/943"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=943"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/943\/revisions"}],"predecessor-version":[{"id":944,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/943\/revisions\/944"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}