{"id":933,"date":"2021-04-07T10:00:29","date_gmt":"2021-04-07T10:00:29","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=933"},"modified":"2021-04-07T10:00:29","modified_gmt":"2021-04-07T10:00:29","slug":"25-mar-2021-colchicine-associated-with-reduced-mortality-and-accelerated-recovery-in-covid-19-patients","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/25-mar-2021-colchicine-associated-with-reduced-mortality-and-accelerated-recovery-in-covid-19-patients\/","title":{"rendered":"(25 Mar 2021) Colchicine- associated with reduced mortality and accelerated recovery in COVID-19 patients"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study<\/p>\n<p>https:\/\/doi.org\/10.1371\/journal.pone.0248276<\/p>\n<p class=\"\">Amongst the 141 COVID-19 patients (118 [83.7%] hospitalized), 70 (50%) received colchicine. The 21-day crude cumulative mortality was 7.5% in the colchicine group and 28.5% in the control group (P = 0.006; adjusted hazard ratio: 0.24 [95%CI: 0.09 to 0.67]); 21-day clinical improvement occurred in 40.0% of the patients on colchicine and in 26.6% of control patients (adjusted relative improvement rate: 1.80 [95%CI: 1.00 to 3.22]). The strong association between the use of colchicine and reduced mortality was further supported by the diverging linear trends of percent daily change in lymphocyte count (P = 0.018), neutrophil-to-lymphocyte ratio (P = 0.003), and in C-reactive protein levels (P = 0.009). Colchicine was stopped because of transient side effects (diarrhea or skin rashes) in 7% of patients. In this retrospective cohort study colchicine was associated with reduced mortality and accelerated recovery in COVID-19 patients.&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study https:\/\/doi.org\/10.1371\/journal.pone.0248276 Amongst the 141 COVID-19 patients (118 [83.7%] hospitalized), 70 (50%) received colchicine. The 21-day crude cumulative mortality was 7.5% in the colchicine group and 28.5%&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/25-mar-2021-colchicine-associated-with-reduced-mortality-and-accelerated-recovery-in-covid-19-patients\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(25 Mar 2021) Colchicine- associated with reduced mortality and accelerated recovery in COVID-19 patients&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[101,4],"tags":[102],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/933"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=933"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/933\/revisions"}],"predecessor-version":[{"id":934,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/933\/revisions\/934"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}