{"id":90,"date":"2020-04-21T08:40:14","date_gmt":"2020-04-21T08:40:14","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=90"},"modified":"2020-05-12T06:08:08","modified_gmt":"2020-05-12T06:08:08","slug":"05-march-2020-camostat-mesylate-blocks-tmprss2-activity-which-prevents-virus-entry-into-host","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/05-march-2020-camostat-mesylate-blocks-tmprss2-activity-which-prevents-virus-entry-into-host\/","title":{"rendered":"(05 March 2020) Camostat mesylate- blocks TMPRSS2 activity, which prevents virus entry into host"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor<\/p>\n<p>https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)30229-4?rss=yes)#secsectitle0035<\/p>\n<p class=\"\">TMPRSS2 is dispensable for development and homeostasis (Kim et al., 2006) and thus constitutes an attractive drug target. In this context, it is noteworthy that the serine protease inhibitor Camostat mesylate, which blocks TMPRSS2 activity (Kawase et al., 2012; Zhou et al., 2015), has been approved in Japan for human use, but for an unrelated indication<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)30229-4?rss=yes)#secsectitle0035 TMPRSS2 is dispensable for development and homeostasis (Kim et al., 2006) and thus constitutes an attractive drug target. In this context, it&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/05-march-2020-camostat-mesylate-blocks-tmprss2-activity-which-prevents-virus-entry-into-host\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(05 March 2020) Camostat mesylate- blocks TMPRSS2 activity, which prevents virus entry into host&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[17,4],"tags":[48],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/90"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=90"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/90\/revisions"}],"predecessor-version":[{"id":91,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/90\/revisions\/91"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=90"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=90"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=90"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}