{"id":869,"date":"2021-03-01T05:58:37","date_gmt":"2021-03-01T05:58:37","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=869"},"modified":"2021-03-01T05:58:37","modified_gmt":"2021-03-01T05:58:37","slug":"21-feb-2021-tocilizumab-associated-with-reduced-mortality","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/21-feb-2021-tocilizumab-associated-with-reduced-mortality\/","title":{"rendered":"(21 Feb 2021) Tocilizumab- associated with reduced mortality"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>Tocilizumab Treatment in Critically Ill Patients with COVID-19: A Retrospective Observational Study<\/p>\n<p>https:\/\/doi.org\/10.1016\/j.ijid.2021.02.057<\/p>\n<p class=\"\">More tocilizumab-treated patients required mechanical ventilation (44\/55, 80%) compared to non-treated patients (15\/41, 37%; p&lt;0.001). Of 55 patients treated with tocilizumab, 32 (58%) were on mechanical ventilation at the time of administration and 12 (22%) progressed to mechanical ventilation after treatment. Thirty of 44 (68%) treated ventilated patients were intubated within one day of tocilizumab. Fewer deaths were observed among tocilizumab-treated patients, both in the overall population (15% vs. 37%; p=0.02) and among the subgroup of patients requiring mechanical ventilation (14% vs. 60%; p=0.001). Secondary infections were not different between the two groups (tocilizumab: 31%, non-tocilizumab: 17%; p=0.16) and were predominantly related to invasive devices, such as urinary and central venous catheters. Tocilizumab treatment was associated with fewer deaths compared to non-treatment despite predominantly being used in patients with more advanced respiratory disease.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Tocilizumab Treatment in Critically Ill Patients with COVID-19: A Retrospective Observational Study https:\/\/doi.org\/10.1016\/j.ijid.2021.02.057 More tocilizumab-treated patients required mechanical ventilation (44\/55, 80%) compared to non-treated patients (15\/41, 37%; p&lt;0.001). Of 55 patients treated with tocilizumab, 32 (58%) were on mechanical ventilation&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/21-feb-2021-tocilizumab-associated-with-reduced-mortality\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(21 Feb 2021) Tocilizumab- associated with reduced mortality&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,18],"tags":[27],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/869"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=869"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/869\/revisions"}],"predecessor-version":[{"id":870,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/869\/revisions\/870"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}