{"id":829,"date":"2021-02-16T06:00:43","date_gmt":"2021-02-16T06:00:43","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=829"},"modified":"2021-02-16T06:00:43","modified_gmt":"2021-02-16T06:00:43","slug":"06-feb-2021-tocilizumab-combination-therapy-of-tcz-and-steroids-is-likely-to-be-safe-and-effective","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/06-feb-2021-tocilizumab-combination-therapy-of-tcz-and-steroids-is-likely-to-be-safe-and-effective\/","title":{"rendered":"(06 Feb 2021) Tocilizumab- Combination therapy of TCZ and Steroids is likely to be safe and effective"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome: A single center experience from Pune, Western India<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.04.21249959v1<\/p>\n<div id=\"sec-3\" class=\"subsection\">\n<p id=\"p-5\" class=\"\">Out of 2831 admitted patients, 515 (24.3% females) were administered TCZ and steroids. Median age of the cohort was 57 (IQR: 46.5, 66) years. Almost 72 % patients had preexisting co-morbidities. Median time to TCZ administration since onset of symptoms was 9 days (IQR: 7, 11). 63% patients needed intensive care unit (ICU) admission. Mechanical ventilation was required in 242 (47%) patients. Of these, 44.2% (107\/242) recovered and were weaned off the ventilator. There were 135 deaths (26.2%), while 380 patients (73.8%) had clinical improvement. Infectious complications like hospital acquired pneumonia, bloodstream bacterial and fungal infections were observed in 2.13 %, 2.13 % and 0.06 % patients respectively. Age \u2265 60 years (p=0.014), presence of co-morbidities like hypertension (p = 0.011), IL-6 \u2265 100 pg\/ml (p = 0.002), D-dimer \u2265 1000 ng\/ml (p &lt; 0.0001), CT severity index \u2265 18 (p &lt; 0.0001) and systemic complications like lung fibrosis (p = 0.019), cardiac arrhythmia (p &lt; 0.0001), hypotension (p &lt; 0.0001) and encephalopathy (p &lt; 0.0001) were associated with increased risk of death. Combination therapy of TCZ and Steroids is likely to be safe and effective in the management of COVID-19 associated cytokine release syndrome.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome: A single center experience from Pune, Western India https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.04.21249959v1 Out of 2831 admitted patients, 515 (24.3% females) were administered TCZ and steroids. Median age of the&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/06-feb-2021-tocilizumab-combination-therapy-of-tcz-and-steroids-is-likely-to-be-safe-and-effective\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(06 Feb 2021) Tocilizumab- Combination therapy of TCZ and Steroids is likely to be safe and effective&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,18],"tags":[27],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/829"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=829"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/829\/revisions"}],"predecessor-version":[{"id":830,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/829\/revisions\/830"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}