{"id":821,"date":"2021-02-16T05:04:53","date_gmt":"2021-02-16T05:04:53","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=821"},"modified":"2021-02-16T05:04:53","modified_gmt":"2021-02-16T05:04:53","slug":"05-feb-2021-methylprednisolone-decreased-mortality-as-compared-to-dexamethasone","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/05-feb-2021-methylprednisolone-decreased-mortality-as-compared-to-dexamethasone\/","title":{"rendered":"(05 Feb 2021) Methylprednisolone- decreased mortality as compared to dexamethasone"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients with COVID-19<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.03.21251088v1<\/p>\n<div id=\"sec-1\" class=\"subsection\">\n<p id=\"p-5\" class=\"\">This study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring ICU care. &nbsp;A total of 262 patients were grouped as receiving usual care (n=75), methylprednisolone dosed at least at 1mg\/kg\/day for \u2265 3 days (n=104), or dexamethasone dosed at least at 6 mg for \u2265 7 days (n=83).In this cohort of 262 patients with severe COVID-19, all-cause mortalities in the usual care, methylprednisolone, and dexamethasone groups were 41.3%, 16.4% and 26.5% at 50 days (p &lt;0.01) respectively. In patients requiring mechanical ventilation, mortality was 42% lower in the methylprednisolone group than in the dexamethasone group (hazard ratio 0.48, 95% CI: 0.235-0.956, p=0.0385). In COVID-19 patients requiring mechanical ventilation, sufficiently dosed methylprednisolone can lead to a further decreased mortality as compared to dexamethasone.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients with COVID-19 https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.03.21251088v1 This study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring ICU care. &nbsp;A total&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/05-feb-2021-methylprednisolone-decreased-mortality-as-compared-to-dexamethasone\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(05 Feb 2021) Methylprednisolone- decreased mortality as compared to dexamethasone&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[81,4],"tags":[68,89],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/821"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=821"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/821\/revisions"}],"predecessor-version":[{"id":822,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/821\/revisions\/822"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}