{"id":819,"date":"2021-02-16T05:00:47","date_gmt":"2021-02-16T05:00:47","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=819"},"modified":"2021-02-16T05:00:47","modified_gmt":"2021-02-16T05:00:47","slug":"05-feb-2021-hydroxychlooquine-no-beneficial-effect-or-significant-harm","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/05-feb-2021-hydroxychlooquine-no-beneficial-effect-or-significant-harm\/","title":{"rendered":"(05 Feb 2021) Hydroxychlooquine- No beneficial effect or significant harm"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">HYDROXYCHLOROQUINE FOR THE TREATMENT OF SEVERE RESPIRATORY INFECTION BY COVID-19: A RANDOMIZED CONTROLLED TRIAL<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.01.21250371v1<\/p>\n<p class=\"\">NCT04315896- A total of 214 patients with COVID-19 were recruited, randomized and analyzed. They were hypoxemic with a mean SpO<sub>2<\/sub> of 65% \u00b1 20, tachycardic (pulse rate 108\u00b117 min-<sup>1<\/sup>) and tachypneic (32 \u00b110 min-<sup>1<\/sup>); 162 were under mechanical ventilation at randomization. Thirty-day mortality was similar in both groups (38% in Hydroxychloroquine vs. 41% in placebo, hazard ratio [HR] 0.88, 95% Confidence Interval [95%CI] 0.51-1.53). In the surviving participants, no significant difference was found in secondary outcomes. No beneficial effect or significant harm could be demonstrated in our randomized controlled trial including 214 patients, using relatively low doses of Hydroxychloroquine compared with placebo in hospitalized patients with severe COVID-19.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>HYDROXYCHLOROQUINE FOR THE TREATMENT OF SEVERE RESPIRATORY INFECTION BY COVID-19: A RANDOMIZED CONTROLLED TRIAL https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.01.21250371v1 NCT04315896- A total of 214 patients with COVID-19 were recruited, randomized and analyzed. They were hypoxemic with a mean SpO2 of 65% \u00b1 20, tachycardic&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/05-feb-2021-hydroxychlooquine-no-beneficial-effect-or-significant-harm\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(05 Feb 2021) Hydroxychlooquine- No beneficial effect or significant harm&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[6,4,9],"tags":[10],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/819"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=819"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/819\/revisions"}],"predecessor-version":[{"id":820,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/819\/revisions\/820"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}