{"id":805,"date":"2021-02-01T05:04:58","date_gmt":"2021-02-01T05:04:58","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=805"},"modified":"2021-02-01T05:04:58","modified_gmt":"2021-02-01T05:04:58","slug":"29-jan-2021-corticosteroids-showed-a-statistically-significant-decrease-in-mortality","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/29-jan-2021-corticosteroids-showed-a-statistically-significant-decrease-in-mortality\/","title":{"rendered":"(29 Jan 2021) Corticosteroids- showed a statistically significant decrease in mortality"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response<\/p>\n<p>https:\/\/doi.org\/10.1371\/journal.pone.0243964<\/p>\n<p class=\"\">HDCPT showed a statistically significant decrease in mortality (HR = 0.087 [95% CI 0.021-0.36]; P &lt; 0.001). 30-day time course analysis of laboratory marker tests showed marked differences in pro-inflammatory markers between survivors and non-survivors. As diagnostic criteria to define the patients at risk of developing a COVID-19 hyper-inflammatory response, we propose the following parameters (IL-6 &gt; = 40 pg\/ml, and\/or two of the following: C-reactive protein &gt; = 100 mg\/L, D-dimer &gt; = 1000 ng\/ml, ferritin &gt; = 500 ng\/ml and lactate dehydrogenase &gt; = 300 U\/L). CONCLUSIONS: HDCPT can be an effective intervention to increase COVID-19 survival rates in patients at risk of developing a COVID-19 hyper-inflammatory response, laboratory marker tests can be used to stratify these patients who should be given HDCPT. This study is not a randomized clinical trial (RCT). Future RCTs should be carried out to confirm the efficacy of HDCPT to increase the survival rates of COVID-19.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response https:\/\/doi.org\/10.1371\/journal.pone.0243964 HDCPT showed a statistically significant decrease in mortality (HR = 0.087 [95% CI 0.021-0.36]; P &lt; 0.001). 30-day time course analysis of laboratory&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/29-jan-2021-corticosteroids-showed-a-statistically-significant-decrease-in-mortality\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(29 Jan 2021) Corticosteroids- showed a statistically significant decrease in mortality&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[51,4],"tags":[52],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/805"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=805"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/805\/revisions"}],"predecessor-version":[{"id":806,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/805\/revisions\/806"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=805"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=805"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}