{"id":781,"date":"2021-01-28T11:19:21","date_gmt":"2021-01-28T11:19:21","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=781"},"modified":"2021-01-28T11:20:20","modified_gmt":"2021-01-28T11:20:20","slug":"20-jan-2021-canakinumab-causes-rapid-and-long-lasting-improvement-in-oxygenation-levels","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/20-jan-2021-canakinumab-causes-rapid-and-long-lasting-improvement-in-oxygenation-levels\/","title":{"rendered":"(20 Jan 2021) Canakinumab- causes rapid and long-lasting improvement in oxygenation levels"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>Efficacy of canakinumab in mild or severe COVID-19 pneumonia<\/p>\n<p class=\"\">https:\/\/doi.org\/10.1002\/iid3.400<\/p>\n<p class=\"\">34 patients with mild or severe non intensive care unit (ICU) coronavirus disease 2019 (COVID-19) were enrolled: 17 patients treated with standard therapy and 17 patients treated with a subcutaneous single dose of canakinumab 300 mg. We observed a reduction in inflammation indices and a significant and rapid increase in P\/F ratio in canakinumab group, with improvement of 60.3% after the administration. We reported a significant reduction in oxygen flow in patients treated with canakinumab (-28.6% at T1 vs. T0 and -40.0% at T2 vs. T1). Conversely, the standard group increased the supply of high oxygen at T1 versus T0 (+66.7%), but reduced oxygen flows at T2 versus T1 (-40.0%).&nbsp; In hospitalized adult patients with mild or severe non ICU COVID-19, canakinumab could be a valid therapeutic option. Canakinumab therapy causes rapid and long-lasting improvement in oxygenation levels in the absence of any severe adverse events.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Efficacy of canakinumab in mild or severe COVID-19 pneumonia https:\/\/doi.org\/10.1002\/iid3.400 34 patients with mild or severe non intensive care unit (ICU) coronavirus disease 2019 (COVID-19) were enrolled: 17 patients treated with standard therapy and 17 patients treated with a subcutaneous&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/20-jan-2021-canakinumab-causes-rapid-and-long-lasting-improvement-in-oxygenation-levels\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(20 Jan 2021) Canakinumab- causes rapid and long-lasting improvement in oxygenation levels&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[97,4],"tags":[98],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/781"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=781"}],"version-history":[{"count":2,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/781\/revisions"}],"predecessor-version":[{"id":783,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/781\/revisions\/783"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}