{"id":773,"date":"2021-01-19T10:35:55","date_gmt":"2021-01-19T10:35:55","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=773"},"modified":"2021-01-19T10:35:55","modified_gmt":"2021-01-19T10:35:55","slug":"09-jan-2021-antivirals-discovery-trial-no-improvement-of-the-clinical-status-at-day-15","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/09-jan-2021-antivirals-discovery-trial-no-improvement-of-the-clinical-status-at-day-15\/","title":{"rendered":"(09 Jan 2021) Antivirals, DisCovery trial-No improvement of the clinical status at day 15"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">Antiviral drugs in hospitalized patients with COVID-19 &#8211; the DisCoVeRy trial<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2021.01.08.20248149v1<\/p>\n<p class=\"\">NCT04315948- An open-label, randomized, adaptive, controlled trial, multi-center trial was conducted with 583 COVID-19 inpatients requiring oxygen and\/or ventilatory support&nbsp; from France. Adjusted Odds Ratio (aOR) for the WHO 7-point ordinal scale were not in favor of investigational treatments: lopinavir\/ritonavir <em>versus<\/em>&nbsp;control, aOR 0.83, 95%CI, 0.55 to 1.26, P=0.39; lopinavir\/ritonavir-IFN-\u03b2-1a&nbsp;<em>versus<\/em>&nbsp;control, aOR 0.69, 95%CI, 0.45 to 1.04, P=0.08; hydroxychloroquine&nbsp;<em>versus<\/em> control, aOR 0.93, 95%CI, 0.62 to 1.41, P=0.75. No significant effect on SARS-CoV-2 RNA clearance in respiratory tract was evidenced. Lopinavir\/ritonavir-containing treatments were significantly associated with more SAE.No improvement of the clinical status at day 15 nor SARS-CoV-2 RNA clearance in respiratory tract specimens by studied drugs. This comforts the recent Solidarity findings.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Antiviral drugs in hospitalized patients with COVID-19 &#8211; the DisCoVeRy trial https:\/\/www.medrxiv.org\/content\/10.1101\/2021.01.08.20248149v1 NCT04315948- An open-label, randomized, adaptive, controlled trial, multi-center trial was conducted with 583 COVID-19 inpatients requiring oxygen and\/or ventilatory support&nbsp; from France. Adjusted Odds Ratio (aOR) for the&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/09-jan-2021-antivirals-discovery-trial-no-improvement-of-the-clinical-status-at-day-15\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(09 Jan 2021) Antivirals, DisCovery trial-No improvement of the clinical status at day 15&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[6,4,12],"tags":[41],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/773"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=773"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/773\/revisions"}],"predecessor-version":[{"id":774,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/773\/revisions\/774"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}