{"id":691,"date":"2020-12-05T08:30:32","date_gmt":"2020-12-05T08:30:32","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=691"},"modified":"2020-12-05T08:30:32","modified_gmt":"2020-12-05T08:30:32","slug":"01-dec-2020-hydroxychloroquine-hcq-azt-does-not-facilitate-virologic-cure","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/01-dec-2020-hydroxychloroquine-hcq-azt-does-not-facilitate-virologic-cure\/","title":{"rendered":"(01 Dec 2020) Hydroxychloroquine- HCQ+\/-AZT does not facilitate virologic cure"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19<\/p>\n<p class=\"\">https:\/\/doi.org\/10.1016\/j.eclinm.2020.100645<\/p>\n<p class=\"\">NCT04349592 study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC, and placebo groups had 6 (3.9%), 7 (4.6%), and 9 (5.9%) participants go off study medications before completing the medication course (p = 0.716). Day six PCR results were available for all 152 HC+AZ participants, 149\/152 (98.0%) HC participants, and 147\/152 (96.7%) placebo participants. Day six ITT analysis found no difference (p = 0.821) in groups&#8217; proportions achieving virologic cure: HC+AZ 16\/152 (10.5%), HC 19\/149 (12.8%), placebo 18\/147 (12.2%). Day 14 assessment also showed no association (p = 0.072) between study group and viral cure: HC+AZ 30\/149 (20.1%,), HC 42\/146 (28.8%), placebo 45\/143 (31.5%). There were no serious adverse events. HC+\/-AZ does not facilitate virologic cure in patients with mild or asymptomatic Covid-19.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19 https:\/\/doi.org\/10.1016\/j.eclinm.2020.100645 NCT04349592 study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC,&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/01-dec-2020-hydroxychloroquine-hcq-azt-does-not-facilitate-virologic-cure\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(01 Dec 2020) Hydroxychloroquine- HCQ+\/-AZT does not facilitate virologic cure&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[82,6,4,9],"tags":[60,10],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/691"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=691"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/691\/revisions"}],"predecessor-version":[{"id":692,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/691\/revisions\/692"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}