{"id":579,"date":"2020-10-09T10:00:31","date_gmt":"2020-10-09T10:00:31","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=579"},"modified":"2020-10-09T10:00:31","modified_gmt":"2020-10-09T10:00:31","slug":"08-oct-2020-hydroxychloroquine-ivermectin-and-azithromycin-no-beneficial-effects-of-individual-drugs-or-their-combinations","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/08-oct-2020-hydroxychloroquine-ivermectin-and-azithromycin-no-beneficial-effects-of-individual-drugs-or-their-combinations\/","title":{"rendered":"(08 Oct 2020) Hydroxychloroquine, Ivermectin and Azithromycin- no beneficial effects of individual drugs or their combinations"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">Real-World Effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide Healthcare System in Peru<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2020.10.06.20208066v2<\/p>\n<p class=\"\">Among 5683 patients, 200 received HCT, 203 IVM, 1600 AZIT, 692 HCQ + AZIT, 358 IVM + AZIT, and 2630 received standard of care. The AZIT + HCQ group was associated with 84% higher all-cause mortality hazard rate compared to standard care (wHR=1.84, 95%CI 1.12-3.02). Consistently, AZIT + HCQ treatment was associated with deaths or ICU transfer ICU (wHR=1.49, 95%CI 1.01-2.19), and deaths or oxygen prescription (wHR=1.70, 95%CI 1.07-2.69). HCQ treatment was only associated with death or oxygen prescription (wHR=1.77, 95% CI 1.01-3.11), and IVM was only associated with death or ICU transfer (wHR=1.58, 95%CI 1.11-2.25). No effect was found for AZIT or AZIT + IVM. Conclusion: Our study reported no beneficial effects of hydroxychloroquine, ivermectin, azithromycin, or their combinations. The AZIT+HCQ treatment reported increased risk of all-cause mortality.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Real-World Effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide Healthcare System in Peru https:\/\/www.medrxiv.org\/content\/10.1101\/2020.10.06.20208066v2 Among 5683 patients, 200 received HCT, 203 IVM, 1600 AZIT, 692 HCQ&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/08-oct-2020-hydroxychloroquine-ivermectin-and-azithromycin-no-beneficial-effects-of-individual-drugs-or-their-combinations\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(08 Oct 2020) Hydroxychloroquine, Ivermectin and Azithromycin- no beneficial effects of individual drugs or their combinations&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[82,4,9,16],"tags":[60,10,38],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/579"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=579"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/579\/revisions"}],"predecessor-version":[{"id":580,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/579\/revisions\/580"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}