{"id":574,"date":"2020-10-05T12:41:47","date_gmt":"2020-10-05T12:41:47","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=574"},"modified":"2020-10-05T12:42:46","modified_gmt":"2020-10-05T12:42:46","slug":"04-oct-2020-corticosteroids-significantly-reduced-mortality-in-severe-covid-patients","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/04-oct-2020-corticosteroids-significantly-reduced-mortality-in-severe-covid-patients\/","title":{"rendered":"(04 Oct 2020) Corticosteroids- significantly reduced mortality in severe COVID patients"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">Corticosteroid pulses for hospitalized patients with COVID-19. Effects on mortality and in-hospital stay.<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2020.09.30.20204719v1<\/p>\n<p class=\"\">From 2933 patients in a multicenter retrospective cohort study, 257 fulfilled the inclusion and exclusion criteria. 124 patients were on corticosteroid pulses, and 133 were not. 30,3% (37\/122) of patients died in the corticosteroid pulses group and 42,9% (57\/133) in the non-exposed cohort. These differences (12,6%) were statically significant (log-rank 4.72, p=0,03). We performed PSM using the exact method. Mortality differences remained in the PSM group (log-rank 5.31, p=0,021) and were still significant after a Cox regression model (HR for corticosteroid pulses 0,561, p= 0,039). There were no significant differences in intensive care admission rate (p=0,173). The hospital stay was longer in the corticosteroid group (p&lt;0,001). This study provides evidence about treatment with corticosteroid pulses in severe COVID-19 that might significantly reduce mortality. Strict inclusion and exclusion criteria with that selection process set a reliable frame to compare mortality in both exposed and non-exposed groups.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Corticosteroid pulses for hospitalized patients with COVID-19. Effects on mortality and in-hospital stay. https:\/\/www.medrxiv.org\/content\/10.1101\/2020.09.30.20204719v1 From 2933 patients in a multicenter retrospective cohort study, 257 fulfilled the inclusion and exclusion criteria. 124 patients were on corticosteroid pulses, and 133 were not.&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/04-oct-2020-corticosteroids-significantly-reduced-mortality-in-severe-covid-patients\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(04 Oct 2020) Corticosteroids- significantly reduced mortality in severe COVID patients&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[51,4],"tags":[52],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/574"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=574"}],"version-history":[{"count":2,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/574\/revisions"}],"predecessor-version":[{"id":576,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/574\/revisions\/576"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}