{"id":556,"date":"2020-09-29T12:02:45","date_gmt":"2020-09-29T12:02:45","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=556"},"modified":"2020-09-29T12:02:45","modified_gmt":"2020-09-29T12:02:45","slug":"27-sep-2020-tocilizumab-associated-with-a-lower-risk-of-death-or-icu-or-death-in-patients-with-higher-crp-levels","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/27-sep-2020-tocilizumab-associated-with-a-lower-risk-of-death-or-icu-or-death-in-patients-with-higher-crp-levels\/","title":{"rendered":"(27 Sep 2020) Tocilizumab- associated with a lower risk of death or ICU or death in patients with higher CRP levels"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Effects of tocilizumab on mortality in hospitalized patients with COVID-19: A multicenter cohort study<\/p>\n<p>https:\/\/doi.org\/10.1016\/j.cmi.2020.09.021<\/p>\n<p class=\"\">A total of 1,229 patients were analyzed, with 261 patients (61 deaths) in the tocilizumab group and 969 patients (120 deaths) in the control group. In the adjusted marginal structural models, a significant interaction between tocilizumab use and high C-reactive protein (CRP) levels was detected. Tocilizumab was associated with decreased risk of death (aHR 0.34, 95% CI 0.16-0.72, p=0.005) and ICU admission or death (aHR 0.38, 95% CI 0.19-0.81, p=0.011) among patients with baseline CRP &gt;150 mg\/L, but not among those with CRP &lt;\/=150 mg\/L. Exploratory subgroup analyses yielded point estimates that were consistent with these findings. In this large observational study, tocilizumab was associated with a lower risk of death or ICU or death in patients with higher CRP levels.&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Effects of tocilizumab on mortality in hospitalized patients with COVID-19: A multicenter cohort study https:\/\/doi.org\/10.1016\/j.cmi.2020.09.021 A total of 1,229 patients were analyzed, with 261 patients (61 deaths) in the tocilizumab group and 969 patients (120 deaths) in the control group.&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/27-sep-2020-tocilizumab-associated-with-a-lower-risk-of-death-or-icu-or-death-in-patients-with-higher-crp-levels\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(27 Sep 2020) Tocilizumab- associated with a lower risk of death or ICU or death in patients with higher CRP levels&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,18],"tags":[27],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/556"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=556"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/556\/revisions"}],"predecessor-version":[{"id":557,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/556\/revisions\/557"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}