{"id":469,"date":"2020-08-21T09:38:31","date_gmt":"2020-08-21T09:38:31","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=469"},"modified":"2020-08-21T09:38:31","modified_gmt":"2020-08-21T09:38:31","slug":"14-aug-2020-tocilizumab-found-safe-in-patients-with-hyperinflammation","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/14-aug-2020-tocilizumab-found-safe-in-patients-with-hyperinflammation\/","title":{"rendered":"(14 Aug 2020) Tocilizumab- found safe in patients with hyperinflammation"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p><strong>First report of tocilizumab use in a cohort of Latin American patients hospitalized for severe COVID-19 pneumonia<\/strong><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1101\/2020.08.12.20173104\">https:\/\/doi.org\/10.1101\/2020.08.12.20173104<\/a><\/p>\n<p class=\"\">In an observational retrospective cohort study, hospitalized patients were evaluated by our multidisciplinary team for eventual use of tocilizumab. 29 patients received tocilizumab. 93.1% were men, 37.9% were obese, and 34.5% had hypertension. Of the 20 patients who were not on MV when receiving tocilizumab, 11 required non-invasive MV, for an average of five days, and one of them required intubation. A-a gradient, PaO2\/FiO2, and inflammation parameters improved significantly. A better lymphocyte count, which improved significantly after tocilizumab use, was significantly associated with less use of MV. Five patients presented positive culture samples after tocilizumab, three being of clinical significance. A lower lymphocyte count was associated with having a positive culture. No other significant adverse events were seen. Conclusion: Our study suggests the utility and shows the safety of tocilizumab use in COVID-19 patients who have respiratory failure and evidence of hyperinflammation.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>First report of tocilizumab use in a cohort of Latin American patients hospitalized for severe COVID-19 pneumonia https:\/\/doi.org\/10.1101\/2020.08.12.20173104 In an observational retrospective cohort study, hospitalized patients were evaluated by our multidisciplinary team for eventual use of tocilizumab. 29 patients received&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/14-aug-2020-tocilizumab-found-safe-in-patients-with-hyperinflammation\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(14 Aug 2020) Tocilizumab- found safe in patients with hyperinflammation&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,18],"tags":[27],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/469"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=469"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/469\/revisions"}],"predecessor-version":[{"id":470,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/469\/revisions\/470"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}