{"id":403,"date":"2020-07-25T09:56:56","date_gmt":"2020-07-25T09:56:56","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=403"},"modified":"2020-07-27T10:08:17","modified_gmt":"2020-07-27T10:08:17","slug":"23-july-2020-hydroxychloroquine-alone-or-with-azithromycin-did-not-improve-clinical-status-at-15-days","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/23-july-2020-hydroxychloroquine-alone-or-with-azithromycin-did-not-improve-clinical-status-at-15-days\/","title":{"rendered":"(23 July 2020) Hydroxychloroquine- alone or with azithromycin, did not improve clinical status at 15 days"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"m-article-header__title f-h18\"><span class=\"title_default\">Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19<\/span><\/p>\n<p class=\"\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2019014<\/p>\n<p class=\"\">A multicenter, randomized, open-label, three-group, controlled trial (<a class=\"ext-link\" href=\"http:\/\/clinicaltrials.gov\/show\/NCT04322123\" target=\"_blank\" rel=\"noopener noreferrer\">NCT04322123<span class=\"sr-only\">. opens in new tab<\/span><\/a>) involving hospitalized patients with suspected or confirmed Covid-19 who were receiving either no supplemental oxygen or a maximum of 4 liters per minute of supplemental oxygen was conducted. A total of 667 patients underwent randomization; 504 patients had confirmed Covid-19 and were included in the modified intention-to-treat analysis. As compared with standard care, the proportional odds of having a higher score on the seven-point ordinal scale at 15 days was not affected by either hydroxychloroquine alone (odds ratio, 1.21; 95% confidence interval [CI], 0.69 to 2.11; P=1.00) or hydroxychloroquine plus azithromycin (odds ratio, 0.99; 95% CI, 0.57 to 1.73; P=1.00). Prolongation of the corrected QT interval and elevation of liver-enzyme levels were more frequent in patients receiving hydroxychloroquine, alone or with azithromycin, than in those who were not receiving either agent. Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19 https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2019014 A multicenter, randomized, open-label, three-group, controlled trial (NCT04322123. opens in new tab) involving hospitalized patients with suspected or confirmed Covid-19 who were receiving either no supplemental oxygen or a maximum of&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/23-july-2020-hydroxychloroquine-alone-or-with-azithromycin-did-not-improve-clinical-status-at-15-days\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(23 July 2020) Hydroxychloroquine- alone or with azithromycin, did not improve clinical status at 15 days&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,9],"tags":[10],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/403"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=403"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/403\/revisions"}],"predecessor-version":[{"id":404,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/403\/revisions\/404"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}