{"id":369,"date":"2020-07-15T09:17:53","date_gmt":"2020-07-15T09:17:53","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=369"},"modified":"2020-07-15T09:17:53","modified_gmt":"2020-07-15T09:17:53","slug":"14-july-2020-proton-pump-inhibitors-pre-hospitalization-ppi-use-is-associated-with-increased-mortality-and-mv-support","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/14-july-2020-proton-pump-inhibitors-pre-hospitalization-ppi-use-is-associated-with-increased-mortality-and-mv-support\/","title":{"rendered":"(14 July 2020) Proton Pump Inhibitors- Pre-hospitalization PPI use is associated with increased mortality and MV support"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Prehospitalization Proton Pump Inhibitor (PPI) use and Clinical Outcomes in COVID-19<\/p>\n<p>https:\/\/doi.org\/10.1101\/2020.07.12.20151084<\/p>\n<p class=\"\">The association between prehospitalization PPI use and clinical outcomes among hospitalized COVID-19 patients was studied.&nbsp; In the study, 15.6% of hospitalized COVID-19 patients were on PPIs at home. Mortality among PPI-users was 2.3 times higher than non-users, along with 2.5 times higher risk of mechanical ventilation. This relationship existed even after adjusting for confounding variables.These results warrant further investigation in prospective studies to evaluate if PPI-induced hypochlorhydria is associated with worse outcomes, including mortality because of the omnipresence of ACE-2 in the gastrointestinal tract.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Prehospitalization Proton Pump Inhibitor (PPI) use and Clinical Outcomes in COVID-19 https:\/\/doi.org\/10.1101\/2020.07.12.20151084 The association between prehospitalization PPI use and clinical outcomes among hospitalized COVID-19 patients was studied.&nbsp; In the study, 15.6% of hospitalized COVID-19 patients were on PPIs at home.&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/14-july-2020-proton-pump-inhibitors-pre-hospitalization-ppi-use-is-associated-with-increased-mortality-and-mv-support\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(14 July 2020) Proton Pump Inhibitors- Pre-hospitalization PPI use is associated with increased mortality and MV support&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,72],"tags":[73],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/369"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=369"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/369\/revisions"}],"predecessor-version":[{"id":370,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/369\/revisions\/370"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}