{"id":355,"date":"2020-07-08T08:38:35","date_gmt":"2020-07-08T08:38:35","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=355"},"modified":"2020-07-08T08:38:35","modified_gmt":"2020-07-08T08:38:35","slug":"07-july-2020-tocilizumab-limited-clinical-improvement-in-patients","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/07-july-2020-tocilizumab-limited-clinical-improvement-in-patients\/","title":{"rendered":"(07 July 2020) Tocilizumab- limited clinical improvement in patients"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p><strong>Tocilizumab in patients with severe COVID\u201019: A single\u2010center observational analysis<\/strong><\/p>\n<p class=\"\"><a href=\"https:\/\/doi.org\/10.1002\/jmv.26191\">https:\/\/doi.org\/10.1002\/jmv.26191<\/a><\/p>\n<p class=\"\">This is a retrospective single\u2010center analysis of the records of patients diagnosed with COVID\u201019 who received tocilizumab. Outcomes, including clinical improvement, mortality and changes in oxygen\u2010support at 24, 48, and 72\u2009hours, and 7, 14, and 28 days post\u2010tocilizumab, are reported. Sixty\u2010six patients received tocilizumab at a mean dose of 724\u2009mg (7.4\u2009mg\/kg), 3.7 days from admission. Seven days after tocilizumab, ten patients (15.2%) had clinical improvement in their oxygenation status, and there was a 95% decrease in CRP. Within 14 days of treatment, 29% of patients had clinical improvement, 20% had minimal or no improvement, 17% worsened, 27% died, and 7% were transferred to an outside hospital. Ultimately, 42% of all patients that received tocilizumab expired and 49% were discharged. This study found limited clinical improvement in patients that received tocilizumab in the setting of severe COVID\u201019. Clinical trials are ongoing to further evaluate tocilizumab&#8217;s benefit in this patient population.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Tocilizumab in patients with severe COVID\u201019: A single\u2010center observational analysis https:\/\/doi.org\/10.1002\/jmv.26191 This is a retrospective single\u2010center analysis of the records of patients diagnosed with COVID\u201019 who received tocilizumab. Outcomes, including clinical improvement, mortality and changes in oxygen\u2010support at 24, 48,&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/07-july-2020-tocilizumab-limited-clinical-improvement-in-patients\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(07 July 2020) Tocilizumab- limited clinical improvement in patients&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,18],"tags":[27],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/355"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=355"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/355\/revisions"}],"predecessor-version":[{"id":356,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/355\/revisions\/356"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=355"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}