{"id":350,"date":"2020-07-07T06:00:22","date_gmt":"2020-07-07T06:00:22","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=350"},"modified":"2020-07-07T06:00:22","modified_gmt":"2020-07-07T06:00:22","slug":"06-july-2020-hydroxychloroquine-use-of-hydroxychloroquine-alone-and-in-combination-with-azithromycin-was-associated-with-significant-reduction-in-hospital-mortality","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/06-july-2020-hydroxychloroquine-use-of-hydroxychloroquine-alone-and-in-combination-with-azithromycin-was-associated-with-significant-reduction-in-hospital-mortality\/","title":{"rendered":"(06 July 2020) Hydroxychloroquine- use of hydroxychloroquine alone and in combination with azithromycin was associated with significant reduction in-hospital mortality"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19<\/p>\n<p class=\"\"><a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.06.099\">https:\/\/doi.org\/10.1016\/j.ijid.2020.06.099<\/a><\/p>\n<p class=\"\">Of 2,541 patients, with a median total hospitalization time of 6 days (IQR: 4-10 days), median age was 64 years (IQR:53-76 years), 51% male, 56% African American, with median time to follow-up of 28.5 days (IQR:3-53). Overall in-hospital mortality was 18.1% (95% CI:16.6%-19.7%); by treatment: hydroxychloroquine + azithromycin, 157\/783 (20.1% [95% CI: 17.3%-23.0%]), hydroxychloroquine alone, 162\/1202 (13.5% [95% CI: 11.6%-15.5%]), azithromycin alone, 33\/147 (22.4% [95% CI: 16.0%-30.1%]), and neither drug, 108\/409 (26.4% [95% CI: 22.2%-31.0%]). Primary cause of mortality was respiratory failure (88%); no patient had documented torsades de pointes. From Cox regression modeling, predictors of mortality were age&gt;65 years (HR:2.6 [95% CI:1.9-3.3]), white race (HR:1.7 [95% CI:1.4-2.1]), CKD (HR:1.7 [95%CI:1.4-2.1]), reduced O<sub>2<\/sub> saturation level on admission (HR:1.5 [95%CI:1.1-2.1]), and ventilator use during admission (HR: 2.2 [95%CI:1.4-3.3]). Hydroxychloroquine provided a 66% hazard ratio reduction, and hydroxychloroquine + azithromycin 71% compared to neither treatment (p &lt; 0.001). In this multi-hospital assessment, when controlling for COVID-19 risk factors, treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality.&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19 https:\/\/doi.org\/10.1016\/j.ijid.2020.06.099 Of 2,541 patients, with a median total hospitalization time of 6 days (IQR: 4-10 days), median age was 64 years (IQR:53-76 years), 51% male, 56% African American, with&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/06-july-2020-hydroxychloroquine-use-of-hydroxychloroquine-alone-and-in-combination-with-azithromycin-was-associated-with-significant-reduction-in-hospital-mortality\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(06 July 2020) Hydroxychloroquine- use of hydroxychloroquine alone and in combination with azithromycin was associated with significant reduction in-hospital mortality&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,9],"tags":[60,59],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/350"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=350"}],"version-history":[{"count":2,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/350\/revisions"}],"predecessor-version":[{"id":354,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/350\/revisions\/354"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}