{"id":293,"date":"2020-06-20T04:40:08","date_gmt":"2020-06-20T04:40:08","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=293"},"modified":"2020-06-29T06:56:57","modified_gmt":"2020-06-29T06:56:57","slug":"20-june-2020-hydroxychloroquine-no-evidence-for-efficacy-of-hcq-or-hcq-combined-with-azi-on-28-day-mortality","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/20-june-2020-hydroxychloroquine-no-evidence-for-efficacy-of-hcq-or-hcq-combined-with-azi-on-28-day-mortality\/","title":{"rendered":"(20 June 2020) Hydroxychloroquine- no evidence for efficacy of HCQ or HCQ combined with AZI on 28-day mortality"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France<\/p>\n<p class=\"\">https:\/\/doi.org\/10.1101\/2020.06.16.20132597<\/p>\n<p class=\"\">In a retrospective study involving large non-selected population of inpatients hospitalized for COVID-19 infection in 39 hospitals in France and robust methodological approaches, no evidence for efficacy of HCQ or HCQ combined with AZI on 28-day mortality was observed. A total of 4,642 patients (mean age: 66.1 \u00b1 18; males: 2,738 (59%)) were included, of whom 623 (13.4%) received HCQ alone, 227 (5.9%) received HCQ plus AZI, and 3,792 (81.7%) neither drug. &nbsp;After accounting for confounding, no statistically significant difference was observed between the \u2018HCQ\u2019 and \u2018Neither drug\u2019 groups for 28-day mortality: AIPTW absolute difference in ATE was +1.24% (-5.63 to 8.12), ratio in ATE 1.05 (0.77 to 1.33). 28-day discharge rates were statistically significantly higher in the \u2018HCQ\u2019 group: AIPTW absolute difference in ATE (+11.1% [3.30 to 18.9]), ratio in ATE (1.25 [1.07 to 1.42]). As for the \u2018HCQ+AZI\u2019 vs neither drug, trends for significant differences and ratios in AIPTW ATE were found suggesting higher mortality rates in the former group (difference in ATE +9.83% [-0.51 to 20.17], ratio in ATE 1.40 [0.98 to 1.81];p=0.062).<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France https:\/\/doi.org\/10.1101\/2020.06.16.20132597 In a retrospective study involving large non-selected population of inpatients hospitalized for COVID-19 infection in&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/20-june-2020-hydroxychloroquine-no-evidence-for-efficacy-of-hcq-or-hcq-combined-with-azi-on-28-day-mortality\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(20 June 2020) Hydroxychloroquine- no evidence for efficacy of HCQ or HCQ combined with AZI on 28-day mortality&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,9],"tags":[10],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/293"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=293"}],"version-history":[{"count":3,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/293\/revisions"}],"predecessor-version":[{"id":321,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/293\/revisions\/321"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}