{"id":225,"date":"2020-05-22T05:28:51","date_gmt":"2020-05-22T05:28:51","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=225"},"modified":"2020-05-22T05:28:51","modified_gmt":"2020-05-22T05:28:51","slug":"21-may-2020-lopinavir-ritonavir-earlier-administration-of-lpv-r-treatment-could-shorten-viral-shedding-duration","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/21-may-2020-lopinavir-ritonavir-earlier-administration-of-lpv-r-treatment-could-shorten-viral-shedding-duration\/","title":{"rendered":"(21 May 2020) Lopinavir\/Ritonavir- Earlier administration of LPV\/r treatment could shorten viral shedding duration"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p id=\"page-title\" class=\"highwire-cite-title\">Factors associated with prolonged viral shedding and impact of Lopinavir\/Ritonavir treatment in hospitalised non-critically ill patients with SARS-CoV-2 infection<\/p>\n<p class=\"\">https:\/\/erj.ersjournals.com\/content\/early\/2020\/05\/13\/13993003.00799-2020<\/p>\n<p class=\"\">In a retrospective study of the 120 patients, 78 patients (65%) were administered with LPV\/r treatment. The median duration of SARS-CoV-2 shedding in LPV\/r treatment group was 22\u2005days, which was significantly shorter than that in no LPV\/r treatment group (28.5\u2005days). Patients who initiated LPV\/r treatment within 10\u2005days from symptom onset had a shorter duration of SARS-CoV-2 RNA shedding compared with those without LPV\/r treatment (median 19\u2005days&nbsp;<em>versus<\/em> 28.5\u2005days, log-rank p&lt;0.001). In contrast, the median duration of viral shedding did not differ between patients who initiated LPV\/r treatment &gt;10\u2005days from symptom onset and patients who did not receive LPV\/r treatment (median 27.5\u2005days&nbsp;<em>versus<\/em> 28.5\u2005days.Earlier administration of LPV\/r treatment may shorten the duration of SARS-CoV-2 RNA shedding.<\/p>\n<p class=\"\">&nbsp;<\/p>\n<p class=\"\">&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Factors associated with prolonged viral shedding and impact of Lopinavir\/Ritonavir treatment in hospitalised non-critically ill patients with SARS-CoV-2 infection https:\/\/erj.ersjournals.com\/content\/early\/2020\/05\/13\/13993003.00799-2020 In a retrospective study of the 120 patients, 78 patients (65%) were administered with LPV\/r treatment. The median duration of&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/21-may-2020-lopinavir-ritonavir-earlier-administration-of-lpv-r-treatment-could-shorten-viral-shedding-duration\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(21 May 2020) Lopinavir\/Ritonavir- Earlier administration of LPV\/r treatment could shorten viral shedding duration&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,12],"tags":[41],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/225"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=225"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/225\/revisions"}],"predecessor-version":[{"id":227,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/225\/revisions\/227"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=225"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=225"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=225"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}