{"id":223,"date":"2020-05-20T12:25:39","date_gmt":"2020-05-20T12:25:39","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=223"},"modified":"2020-05-20T12:25:39","modified_gmt":"2020-05-20T12:25:39","slug":"19-may-2020-lopinavir-ritonavir-higher-concentrations-are-required-to-reach-the-assumed-ec50","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/19-may-2020-lopinavir-ritonavir-higher-concentrations-are-required-to-reach-the-assumed-ec50\/","title":{"rendered":"(19 May 2020) Lopinavir\/Ritonavir- higher concentrations are required to reach the assumed EC50"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Pharmacokinetics of Lopinavir and Ritonavir in Patients Hospitalized With Coronavirus Disease 2019 (COVID-19)<\/p>\n<p class=\"\">https:\/\/www.acpjournals.org\/doi\/10.7326\/M20-1550<\/p>\n<p class=\"\">This reports the first pharmacokinetic data of lopinavir and ritonavir in patients hospitalized with COVID-19. Lopinavir trough levels were approximately 2-fold higher in COVID &nbsp;population than in patients with HIV receiving the same dose (7.1 \u03bcg\/mL). Despite the approximately 2-fold higher<br \/>\nlopinavir trough concentrations in&nbsp; sample of patients with COVID-19 compared with patients with HIV, approximately 60- to 120-fold higher concentrations are required to reach the assumed EC50 at trough levels, making effective treatment of COVID-19 with lopinavir and ritonavir at the currently used doses unlikely.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Pharmacokinetics of Lopinavir and Ritonavir in Patients Hospitalized With Coronavirus Disease 2019 (COVID-19) https:\/\/www.acpjournals.org\/doi\/10.7326\/M20-1550 This reports the first pharmacokinetic data of lopinavir and ritonavir in patients hospitalized with COVID-19. Lopinavir trough levels were approximately 2-fold higher in COVID &nbsp;population than&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/19-may-2020-lopinavir-ritonavir-higher-concentrations-are-required-to-reach-the-assumed-ec50\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(19 May 2020) Lopinavir\/Ritonavir- higher concentrations are required to reach the assumed EC50&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,12],"tags":[41],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/223"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=223"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/223\/revisions"}],"predecessor-version":[{"id":224,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/223\/revisions\/224"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}