{"id":186,"date":"2020-05-18T10:39:15","date_gmt":"2020-05-18T10:39:15","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=186"},"modified":"2020-05-18T10:39:15","modified_gmt":"2020-05-18T10:39:15","slug":"16-may-2020-anakinra-beneficial-for-treating-severe-covid-19-patients-with-shlh","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/16-may-2020-anakinra-beneficial-for-treating-severe-covid-19-patients-with-shlh\/","title":{"rendered":"(16 May 2020) Anakinra- beneficial for treating severe COVID-19 patients with sHLH"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">FAVORABLE ANAKINRA RESPONSES IN SEVERE COVID-19 PATIENTS WITH SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS<\/p>\n<p class=\"\">https:\/\/doi.org\/10.1016\/j.chom.2020.05.007<\/p>\n<p class=\"\">This&nbsp; report comprises of data from&nbsp; the treatment of eight severe COVID-19 pneumonia patients&#8211; seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in the Netherlands&#8211; with the interleukin-1 receptor antagonist Anakinra. All patients scored positive for the hemophagocytosis score (HScore) and were diagnosed with secondary hemophagocytic lymphohistocytosis (sHLH) characterized by pancytopenia, hyper-coagulation, acute kidney injury and hepatobiliary dysfunction. At the end-of-treatment, ICU patients had less need for vasopressors, significantly improved respiratory function and lower HScore.&nbsp; These data suggest that administration of Anakinra may be beneficial for treating severe COVID-19 patients with sHLH as determined by the HScore and support the need for larger clinical studies to validate this concept.&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>FAVORABLE ANAKINRA RESPONSES IN SEVERE COVID-19 PATIENTS WITH SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS https:\/\/doi.org\/10.1016\/j.chom.2020.05.007 This&nbsp; report comprises of data from&nbsp; the treatment of eight severe COVID-19 pneumonia patients&#8211; seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/16-may-2020-anakinra-beneficial-for-treating-severe-covid-19-patients-with-shlh\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(16 May 2020) Anakinra- beneficial for treating severe COVID-19 patients with sHLH&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[56,4],"tags":[57],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/186"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=186"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/186\/revisions"}],"predecessor-version":[{"id":187,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/186\/revisions\/187"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}