{"id":147,"date":"2020-05-05T06:13:46","date_gmt":"2020-05-05T06:13:46","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=147"},"modified":"2020-05-05T06:13:46","modified_gmt":"2020-05-05T06:13:46","slug":"04-may-2020-tocilizumab-reduced-effects-of-tocilizumab-in-hyperglycemic-patients","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/04-may-2020-tocilizumab-reduced-effects-of-tocilizumab-in-hyperglycemic-patients\/","title":{"rendered":"(04 May 2020) Tocilizumab- reduced effects of Tocilizumab in hyperglycemic patients"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>Negative impact of hyperglycemia on Tocilizumab therapy in COVID-19 patients<\/p>\n<p><a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.04.29.20076570v1\">https:\/\/www.medrxiv.org\/content\/10.1101\/2020.04.29.20076570v1<\/a><\/p>\n<p class=\"\">During a retrospective study on 475 Covid-19 positive patients, 78 patients with pneumonia disease and treated with tocilizumab were further evaluated for a severe outcome (encompassing both the use of mechanical ventilation and\/or death). Thirty-one (39.7%) hyperglycemic and 47 (60.3%) normoglycemic Covid-19 positive patients (blood glucose levels &gt;140 mg\/dl, at admission and\/or during hospital stay) were evaluated. Noteworthy, 20 (64%) of hyperglycemic and 11 (23.4%) of normoglycemic patients were also diabetics (P&lt;0.01). Reduced effects of Tocilizumab in hyperglycemic patients may due to the higher plasma IL-6 levels. Interestingly, when authors added IL-6 levels in a Cox regression model the significance for the tocilizumab effect was lost (p&lt;0.07). In this context, observations evidence that optimal Covid-19 infection management with tocilizumab is not achieved during hyperglycemia both in diabetic and non-diabetic patients.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Negative impact of hyperglycemia on Tocilizumab therapy in COVID-19 patients https:\/\/www.medrxiv.org\/content\/10.1101\/2020.04.29.20076570v1 During a retrospective study on 475 Covid-19 positive patients, 78 patients with pneumonia disease and treated with tocilizumab were further evaluated for a severe outcome (encompassing both the use&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/04-may-2020-tocilizumab-reduced-effects-of-tocilizumab-in-hyperglycemic-patients\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(04 May 2020) Tocilizumab- reduced effects of Tocilizumab in hyperglycemic patients&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,18],"tags":[27],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/147"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=147"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/147\/revisions"}],"predecessor-version":[{"id":148,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/147\/revisions\/148"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}