{"id":143,"date":"2020-05-05T05:46:37","date_gmt":"2020-05-05T05:46:37","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=143"},"modified":"2020-05-05T05:46:37","modified_gmt":"2020-05-05T05:46:37","slug":"01-may-2020-telmisartan-treating-covid-19-patients-prior-to-development-of-ards","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/01-may-2020-telmisartan-treating-covid-19-patients-prior-to-development-of-ards\/","title":{"rendered":"(01 May 2020) Telmisartan- treating COVID-19 patients prior to development of ARDS"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div><\/div>\n<div><\/div>\n<div class=\"col-md-12 col-xs-12 col-sm-12\">Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID\u201019<\/p>\n<p class=\"mod-reset\"><a style=\"color: #c8453c; text-decoration-line: underline; cursor: pointer;\" href=\"https:\/\/doi.org\/10.1002\/ddr.21679\">https:\/\/doi.org\/10.1002\/ddr.21679<\/a><\/p>\n<p>High levels of angiotensin II on the lung interstitium can promote apoptosis initiating an inflammatory process with release of proinflammatory cytokines, establishing a self\u2010powered cascade, leading eventually to ARDS. <em>Telmisartan<\/em> is an angiotensin II receptor blocker used in the therapy. In this commentary article, the authors make the case for the election of telmisartan as such alternative on the basis of its pharmacokinetic and pharmacodynamic properties and present an open\u2010label randomized phase II clinical trial for the evaluation of telmisartan in COVID\u201019 patients (<\/p>\n<p class=\"mod-reset\"><a class=\"\" href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04355936\">NCT04355936<\/a><\/p>\n<p>).<\/p><\/div>\n<\/div>\n<div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID\u201019 https:\/\/doi.org\/10.1002\/ddr.21679 High levels of angiotensin II on the lung interstitium can promote apoptosis initiating an inflammatory process with release of proinflammatory cytokines, establishing a self\u2010powered cascade, leading eventually to ARDS. Telmisartan&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/01-may-2020-telmisartan-treating-covid-19-patients-prior-to-development-of-ards\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(01 May 2020) Telmisartan- treating COVID-19 patients prior to development of ARDS&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,28],"tags":[29],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/143"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/143\/revisions"}],"predecessor-version":[{"id":144,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/143\/revisions\/144"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}