{"id":123,"date":"2020-04-29T12:29:27","date_gmt":"2020-04-29T12:29:27","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=123"},"modified":"2020-05-12T05:15:01","modified_gmt":"2020-05-12T05:15:01","slug":"27-april-2020-remdesivir-potently-inhibits-sars-cov-2-replication-in-human-lung-cells-ec50-0-01-%ce%bcm","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/27-april-2020-remdesivir-potently-inhibits-sars-cov-2-replication-in-human-lung-cells-ec50-0-01-%ce%bcm\/","title":{"rendered":"(27 April 2020) Remdesivir- potently inhibits SARS-CoV-2 replication in human lung cells (EC50 = 0.01 \u03bcM)"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p><strong>Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.<\/strong><\/p>\n<p class=\"\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.27.064279v1\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.27.064279v1<\/a><\/p>\n<p class=\"\">To rapidly evaluate in vivo efficacy, authors have&nbsp; engineered a chimeric SARS- CoV encoding the viral target of Remdesivir, the RNA-dependent RNA polymerase, of SARS-CoV-2. In mice infected with chimeric virus, therapeutic RDV administration diminished lung viral load and improved pulmonary function as compared to vehicle treated animals. These data provide evidence that RDV is potently active against SARS-CoV-2 in vitro and in vivo, supporting its further clinical testing for treatment of COVID-19.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.27.064279v1 To rapidly evaluate in vivo efficacy, authors have&nbsp; engineered a chimeric SARS- CoV encoding the viral target of Remdesivir, the RNA-dependent&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/27-april-2020-remdesivir-potently-inhibits-sars-cov-2-replication-in-human-lung-cells-ec50-0-01-%ce%bcm\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(27 April 2020) Remdesivir- potently inhibits SARS-CoV-2 replication in human lung cells (EC50 = 0.01 \u03bcM)&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,5],"tags":[25],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/123"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=123"}],"version-history":[{"count":2,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/123\/revisions"}],"predecessor-version":[{"id":167,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/123\/revisions\/167"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}