{"id":109,"date":"2020-04-27T05:06:06","date_gmt":"2020-04-27T05:06:06","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=109"},"modified":"2020-05-12T05:20:13","modified_gmt":"2020-05-12T05:20:13","slug":"26-april-2020-human-recombinant-soluble-ace-2-enzyme-hrsace2-can-block-early-entry-of-sars-cov-2-infections-in-host-cells","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/26-april-2020-human-recombinant-soluble-ace-2-enzyme-hrsace2-can-block-early-entry-of-sars-cov-2-infections-in-host-cells\/","title":{"rendered":"(26 April 2020) Human recombinant soluble ACE 2 enzyme &#8211; hrsACE2 can block early entry of SARS-CoV-2 infections in host cells"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p class=\"\">Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.04.004\">https:\/\/doi.org\/10.1016\/j.cell.2020.04.004<\/a><\/p>\n<p>Authors report that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000\u20135,000. An equivalent mouse rsACE2 had no effect. They also show that SARSCoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. The data demonstrates that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 https:\/\/doi.org\/10.1016\/j.cell.2020.04.004 Authors report that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000\u20135,000. An equivalent mouse rsACE2 had no effect. They also&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/26-april-2020-human-recombinant-soluble-ace-2-enzyme-hrsace2-can-block-early-entry-of-sars-cov-2-infections-in-host-cells\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(26 April 2020) Human recombinant soluble ACE 2 enzyme &#8211; hrsACE2 can block early entry of SARS-CoV-2 infections in host cells&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[20,4],"tags":[44,43],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/109"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=109"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/109\/revisions"}],"predecessor-version":[{"id":110,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/109\/revisions\/110"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}