{"id":1060,"date":"2021-05-28T06:02:28","date_gmt":"2021-05-28T06:02:28","guid":{"rendered":"https:\/\/nclinnovations.org\/covid19monitor\/?p=1060"},"modified":"2021-05-28T06:02:28","modified_gmt":"2021-05-28T06:02:28","slug":"23-may-2021-methyl-prednisolone-early-high-dose-reduced-mortality-length-of-hospitalization","status":"publish","type":"post","link":"https:\/\/nclinnovations.org\/covid19monitor\/23-may-2021-methyl-prednisolone-early-high-dose-reduced-mortality-length-of-hospitalization\/","title":{"rendered":"(23 May 2021) Methyl prednisolone- early high dose reduced mortality, length of hospitalization"},"content":{"rendered":"<div class=\"boldgrid-section\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12 col-xs-12 col-sm-12\">\n<p>Role of the early short-course corticosteroids treatment in ARDS caused by COVID-19: A single-center, retrospective analysis<\/p>\n<p class=\"\">https:\/\/doi.org\/10.1016\/j.advms.2021.04.002<\/p>\n<p class=\"\">This is a single-center, retrospective study considering the patients with confirmed COVID-19 pneumonia admitted to our hospital between 9th March and 15(th) June 2020. Two groups were considered: early high-dose of methyl-prednisolone (eHDM; n = 31) and the control group (n = 52). Patients in the eHDM group received the dose of 5-8 mg\/kg\/day of methyl-prednisolone for 2 consecutive days. Significant differences between the two groups were: length of hospitalization (21.5 vs 28.4 days, p = 0.026), length of non-invasive ventilation (NIV) or mechanical ventilation (11.5 vs 14.5 days, p = 0.031), death (5 vs 12, p = 0.006) and clinical improvement (16 vs 11, p=0.018). The following factors were related to in-hospital mortality in the multivariate analysis: comorbidities (OR = 2.919; 95%CI = 1.515-16.705; p&lt;0.001), days from the onset of symptoms and the hospital admission (OR = 1.404; 95%CI = 1.069-12.492; p = 0.011), PaO2\/FiO2 (P\/F) ratio (OR = 3.111; 95%CI = 2.334-16.991; p = 0.009) and eHDM treatment (OR = 0.741; 95%CI = 0.129-0.917; p = 0.007).&nbsp; The eHDM is an interesting and promising approach in the ARDS related to COVID-19 pneumonia, which reduces mortality, length of hospitalization and the need for mechanical ventilation.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Role of the early short-course corticosteroids treatment in ARDS caused by COVID-19: A single-center, retrospective analysis https:\/\/doi.org\/10.1016\/j.advms.2021.04.002 This is a single-center, retrospective study considering the patients with confirmed COVID-19 pneumonia admitted to our hospital between 9th March and 15(th) June&hellip; <span class=\"read-more-span\"><a href=\"https:\/\/nclinnovations.org\/covid19monitor\/23-may-2021-methyl-prednisolone-early-high-dose-reduced-mortality-length-of-hospitalization\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;(23 May 2021) Methyl prednisolone- early high dose reduced mortality, length of hospitalization&#8221;<\/span> <span class=\"genericon genericon-next\"><\/span><\/a><\/span><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"bgseo_title":"","bgseo_description":"","bgseo_robots_index":"index","bgseo_robots_follow":"follow"},"categories":[4,113],"tags":[89],"_links":{"self":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/1060"}],"collection":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/comments?post=1060"}],"version-history":[{"count":1,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/1060\/revisions"}],"predecessor-version":[{"id":1061,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/posts\/1060\/revisions\/1061"}],"wp:attachment":[{"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/media?parent=1060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/categories?post=1060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nclinnovations.org\/covid19monitor\/wp-json\/wp\/v2\/tags?post=1060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}