Remdesivir, Drugs Monitor

(06 Apr 2021) Remdesivir- did not produce improvement in clinical outcomes in moderate to severe COVID-19 cases

April 29, 2021

Clinical outcomes of using remdesivir in patients with moderate to severe COVID-19: A prospective randomised study https://doi.org/10.4103/ija.IJA_149_21 Participants more than 40-years old and with moderate to severe COVID-19 but not on mechanical ventilation were randomly assigned into two groups-remdesivir group… Continue reading "(06 Apr 2021) Remdesivir- did not produce improvement in clinical outcomes in moderate to severe COVID-19 cases"

(25 Mar 2021) Remdesivir- was associated with faster clinical improvement

April 7, 2021

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19 https://doi.org/10.1001/jamanetworkopen.2021.3071 Of 2483 consecutive admissions, 342 individuals received remdesivir, 184 of whom also received corticosteroids and 158 of whom received remdesivir alone. For these… Continue reading "(25 Mar 2021) Remdesivir- was associated with faster clinical improvement"

(24 Mar 2021) Remdesivir- 22.9 % required mechanical ventilation compared to 44.7 % in the control group

April 7, 2021

Clinical and Virologic Effectiveness of Remdesivir Treatment for Severe Coronavirus Disease 2019 (COVID-19) in Korea: a Nationwide Multicenter Retrospective Cohort Study https://doi.org/10.3346/jkms.2021.36.e83 A total of 86 severe COVID-19 patients were evaluated including 48 remdesivir-treated patients. Baseline characteristics were not significantly… Continue reading "(24 Mar 2021) Remdesivir- 22.9 % required mechanical ventilation compared to 44.7 % in the control group"

(10 Mar 2021) Remdesivir- no positive effect on clinical outcomes

April 7, 2021

Efficacy of remdesivir in Japanese patients hospitalised with COVID-19: A large observational study using the COVID-19 Registry Japan https://www.medrxiv.org/content/10.1101/2021.03.09.21253183v1 In total, 1907 of 15,225 patients met our inclusion criteria. After PS matching, 74 patients were assigned to the remdesivir case… Continue reading "(10 Mar 2021) Remdesivir- no positive effect on clinical outcomes"

(03 Dec 2020) Solidarity trials- RDV, HCQ, LPV & IFN regimens had little or no effect on hospitalized patients with Covid-19

December 5, 2020

Repurposed Antiviral Drugs for Covid-19 – Interim WHO Solidarity Trial Results https://doi.org/10.1056/NEJMoa2023184 At 405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including… Continue reading "(03 Dec 2020) Solidarity trials- RDV, HCQ, LPV & IFN regimens had little or no effect on hospitalized patients with Covid-19"

(22 Nov 2020) Remdesivir, Dexamethasone- combination helps reduce mortality

November 27, 2020

Effectiveness of remdesivir with and without dexamethasone in hospitalized patients with COVID-19 https://www.medrxiv.org/content/10.1101/2020.11.19.20234153v1 In a multicenter, retrospective cohort study, 342 received remdesivir and 157 received remdesivir plus dexamethasone. Remdesivir recipients on room air or nasal cannula oxygen had a faster… Continue reading "(22 Nov 2020) Remdesivir, Dexamethasone- combination helps reduce mortality"

(19 Nov 2020) Remdesivir- associated with shorter duration of mechanical ventilation

November 27, 2020

Remdesivir Use in Patients Requiring Mechanical Ventilation due to COVID-19 https://doi.org/10.1093/ofid/ofaa481 113 patients requiring mechanical ventilation were observed for a median of 31 days of follow-up; 32% died, 69% were extubated, and 66% were discharged alive from the hospital. Among… Continue reading "(19 Nov 2020) Remdesivir- associated with shorter duration of mechanical ventilation"

(18 Nov 2020) Remdesivir- study on children showed successful outcomes

November 21, 2020

Compassionate use of remdesivir in children with COVID-19 https://doi.org/10.1007/s00431-020-03876-1 A nationwide multicenter observational study was conducted on children with confirmed SARS-CoV-2 receiving compassionate treatment with RDV in Spain. Eight patients were included in the study, four infants and four older… Continue reading "(18 Nov 2020) Remdesivir- study on children showed successful outcomes"

(10 Nov 2020) Remdesivir- associated with a significant mortality benefit

November 12, 2020

A shorter symptom-onset to remdesivir treatment (SORT) interval is associated with a lower mortality in moderate-to-severe COVID-19: A real-world analysis https://www.medrxiv.org/content/10.1101/2020.11.05.20226373v1.full.pdf Of 350 patients treated with remdesivir, 346 were included for the final analysis (males: 270 [78.0%]; median [range] age:… Continue reading "(10 Nov 2020) Remdesivir- associated with a significant mortality benefit"

(03 Nov 2020) Remdesivir- significantly higher rates of clinical improvement

November 5, 2020

Remdesivir-based therapy improved recovery of patients with COVID-19 in the SARSTer multicentre, real-world study https://doi.org/10.1101/2020.10.30.20215301 The purpose of this study was to evaluate the effectiveness and safety of RDV in patients with COVID-19 in real world settings. Patients were selected… Continue reading "(03 Nov 2020) Remdesivir- significantly higher rates of clinical improvement"

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