Efficacy of Ivermectin in COVID-19 Patients with Mild to Moderate Disease https://www.medrxiv.org/content/10.1101/2021.02.02.21250840v1 NCT04392713-A randomized clinical trial (Trial registration # NCT04392713) was carried out at Combined Military Hospital Lahore from March 15, 2020, to June 15, 2020. In group A, 36 (80%)… Continue reading "(05 Feb 2021) Ivermectin- early viral clearance was observed"
Ivermectin as a potential treatment for mild to moderate COVID-19 – A double blind randomized placebo-controlled trial https://www.medrxiv.org/content/10.1101/2021.01.05.21249310v1 CTRI/2020/08/027225- A total of 115 patients were enrolled for the study of which 112 were included in the final analysis. Of them,… Continue reading "(09 Jan 2021) Ivermectin- negative RT-PCR on day 6 of admission with the use of ivermectin"
Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double blind dose response study in Lagos https://www.medrxiv.org/content/10.1101/2021.01.05.21249131v1 ISRCTN40302986- a translational proof of concept (PoC) randomized, double blind placebo controlled, dose response, parallel group study of IV efficacy… Continue reading "(06 Jan 2021) Ivermectin-12 mg IV regime may have superior efficacy"
A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness https://doi.org/10.1016/j.ijid.2020.11.191 To determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients a randomized, double-blind, placebo-controlled trial of oral… Continue reading "(06 Dec 2020) Ivermectin- 5-day course of ivermectin was found to be safe and effective"
Early COVID-19 Therapy with Azithromycin Plus Nitazoxanide, Ivermectin or Hydroxychloroquine in Outpatient Settings Significantly Reduced Symptoms Compared to Known Outcomes in Untreated Patients https://www.medrxiv.org/content/10.1101/2020.10.31.20223883v1.full.pdf The objective of the present study (NCT04446429) was to elucidate whether the conduction of a full… Continue reading "(04 Nov 2020) Azithromycin, Nitazoxanide, Ivermectin and HCQ- AZT in combination with drugs proven beneficial"
Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study https://www.medrxiv.org/content/10.1101/2020.10.29.20222661v1 A hospital-based matched case-control study was conducted among healthcare workers of AIIMS Bhubaneswar, India, from September to October 2020. Ivermectin prophylaxis… Continue reading "(03 Nov 2020) Ivermectin- associated 73% reduction of COVID-19 infection among healthcare workers"
Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq https://www.medrxiv.org/content/10.1101/2020.10.26.20219345v1 Randomized controlled study (NCT04591600) on 70 COVID-19 patients (48 mild-moderate, 11 severe, and 11 critical patients) treated with 200ug/kg PO of Ivermectin per… Continue reading "(27 Oct 2020) Ivermectin- combination with Doxycycline shows higher success rate when administered early"
Real-World Effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide Healthcare System in Peru https://www.medrxiv.org/content/10.1101/2020.10.06.20208066v2 Among 5683 patients, 200 received HCT, 203 IVM, 1600 AZIT, 692 HCQ… Continue reading "(08 Oct 2020) Hydroxychloroquine, Ivermectin and Azithromycin- no beneficial effects of individual drugs or their combinations"
Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial) https://www.medrxiv.org/content/10.1101/2020.07.07.20145979v1 This Pilot clinical trial was conducted on hospitalized adult patients with mild to moderate COVID-19 diagnosed according to WHO interim guidance. Sixteen Patients received a single dose of… Continue reading "(08 July 2020) Ivermectin- add on use to HCQ and AZT improved effectiveness"
The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID-19 https://ascpt.onlinelibrary.wiley.com/doi/epdf/10.1002/cpt.1889 Ivermectin is unlikely to reach the IC50 in lungs after oral administration of the approved dose or doses 10x higher than the approved… Continue reading "(07 May 2020) Ivermectin- approved dose might not work for COVID 19"
