Interferons, Drugs Monitor

(23 Nov 2020) Interferons – PEG Interferon lambda 1a did not shorten the duration of viral shedding

November 27, 2020

Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial https://www.medrxiv.org/content/10.1101/2020.11.18.20234161v1 In a randomized placebo-controlled trial (NCT04331899 )in 120 patients with mild to moderate COVID-19 to determine whether a single, 180 mcg subcutaneous dose of Peginterferon Lambda-1a… Continue reading "(23 Nov 2020) Interferons – PEG Interferon lambda 1a did not shorten the duration of viral shedding"

(15 Oct 2020) Remdesivir, Hydroxychloroquine, Lopinavir and Interferon- Interim results from Solidarity trial suggests these have little or no effect on hospitalized COVID-19

October 17, 2020

Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results https://www.medrxiv.org/content/10.1101/2020.10.15.20209817v1 The interim results from Solidarity trials (ISRCTN83971151 , NCT04315948 ) are presented. In 405 hospitals in 30 countries 11,266 adults were randomized, with 2750 allocated Remdesivir, 954 Hydroxychloroquine, 1411 Lopinavir, 651 Interferon… Continue reading "(15 Oct 2020) Remdesivir, Hydroxychloroquine, Lopinavir and Interferon- Interim results from Solidarity trial suggests these have little or no effect on hospitalized COVID-19"

(17 June 2020) Interferon beta1- significant recovery in 14 days with IFN-β-1a and conventional therapy

June 19, 2020

Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trial https://www.sciencedirect.com/science/article/pii/S1567576920312893?via%3Dihub In this prospective non-controlled trial (IRCT20151227025726N12), 20 patients were included. They received IFN-β-1a at a dose of 44 µg subcutaneously every other day up to 10 days. All… Continue reading "(17 June 2020) Interferon beta1- significant recovery in 14 days with IFN-β-1a and conventional therapy"

(04 May 2020) Human Type I Interferons – reduced viral titers by 3.4 log in preclinical studies

May 6, 2020

Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection https://doi.org/10.1016/j.antiviral.2020.104811 The sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β) is reported. Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces… Continue reading "(04 May 2020) Human Type I Interferons – reduced viral titers by 3.4 log in preclinical studies"

Tag: Interferons

(23 Nov 2020) Interferons – PEG Interferon lambda 1a did not shorten the duration of viral shedding

(15 Oct 2020) Remdesivir, Hydroxychloroquine, Lopinavir and Interferon- Interim results from Solidarity trial suggests these have little or no effect on hospitalized COVID-19

(17 June 2020) Interferon beta1- significant recovery in 14 days with IFN-β-1a and conventional therapy

(04 May 2020) Human Type I Interferons – reduced viral titers by 3.4 log in preclinical studies