Dexamethasone, Drugs Monitor

(25 Apr 2021) Dexamethasone- showed better survival in severe COVID-19 compared to TCZ

April 30, 2021

Short term survival of critically ill COVID-19 Egyptian patients on assisted ventilation treated by either Dexamethasone or Tocilizumab https://doi.org/10.1038/s41598-021-88086-x 109 critically ill COVID-19 patients randomly assigned to either TCZ therapy (46 patients) or pulse Dexamethasone therapy (63 patients). Kaplan-Meier survival… Continue reading "(25 Apr 2021) Dexamethasone- showed better survival in severe COVID-19 compared to TCZ"

(12 Apr 2021) Methylprednisolone- demonstrated better results compared to dexamethasone in hypoxic patients

April 29, 2021

Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial https://doi.org/10.1186/s12879-021-06045-3 IRCT20200204046369N1- In this prospective triple-blinded randomized controlled trial, we enrolled 86 hospitalized COVID-19 patients from August to November 2020,… Continue reading "(12 Apr 2021) Methylprednisolone- demonstrated better results compared to dexamethasone in hypoxic patients"

(27 Feb 2021) Dexamethasone & Methylprednisolone- mortality was 42% lower in the methylprednisolone group

March 1, 2021

A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients With COVID-19 https://doi.org/10.1177/0885066621994057 A total of 262 patients were grouped as receiving usual care (n = 75), methylprednisolone dosed at least at 1mg/kg/day for >/= 3 days (n = 104),… Continue reading "(27 Feb 2021) Dexamethasone & Methylprednisolone- mortality was 42% lower in the methylprednisolone group"

(21 Feb 2021) Dexamethasone- 60 mg and 150 mg was associated with reduced mortality

March 1, 2021

Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study https://doi.org/10.1111/bcp.14784 Of 12,217 adult patients hospitalized with a positive COVID-19 PT-PCR test, 171 (1.4%) received dexamethasone orally or by intravenous perfusion during the visit.… Continue reading "(21 Feb 2021) Dexamethasone- 60 mg and 150 mg was associated with reduced mortality"

(20 Feb 2021) Dexamethasone- No clinical benefits observed

March 1, 2021

No clinical benefit of high dose corticosteroid administration in patients with COVID-19: A preliminary report of a randomized clinical trial https://www.sciencedirect.com/science/article/pii/S001429992100100X?via%3Dihub IRCT20151227025726N17- The aim of this study was to evaluate the clinical effects of dexamethasone administration in patients with mild… Continue reading "(20 Feb 2021) Dexamethasone- No clinical benefits observed"

(05 Feb 2021) Methylprednisolone- decreased mortality as compared to dexamethasone

February 16, 2021

A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients with COVID-19 https://www.medrxiv.org/content/10.1101/2021.02.03.21251088v1 This study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring ICU care. A total… Continue reading "(05 Feb 2021) Methylprednisolone- decreased mortality as compared to dexamethasone"

(22 Nov 2020) Remdesivir, Dexamethasone- combination helps reduce mortality

November 27, 2020

Effectiveness of remdesivir with and without dexamethasone in hospitalized patients with COVID-19 https://www.medrxiv.org/content/10.1101/2020.11.19.20234153v1 In a multicenter, retrospective cohort study, 342 received remdesivir and 157 received remdesivir plus dexamethasone. Remdesivir recipients on room air or nasal cannula oxygen had a faster… Continue reading "(22 Nov 2020) Remdesivir, Dexamethasone- combination helps reduce mortality"

(18 Nov 2020) Dexamethasone & methylprednisolone- both found to be equally effective

November 21, 2020

Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease https://doi.org/10.1016/j.amsu.2020.11.027 The mean age of patients was 57.91 years in dexamethasone group and 54.86 years in methylprednisolone group. In dexamethasone group, there were 15 (42.8%) critically… Continue reading "(18 Nov 2020) Dexamethasone & methylprednisolone- both found to be equally effective"

(27 Oct 2020) Dexamethasone- associated with decreased mortality among those requiring respiratory support

October 31, 2020

Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study https://www.medrxiv.org/content/10.1101/2020.10.23.20218172v1 Among patients who required respiratory support, the end-point event of death occurred in 10 patients (15.9%) who received dexamethasone and 298 patients (26.4%)… Continue reading "(27 Oct 2020) Dexamethasone- associated with decreased mortality among those requiring respiratory support"

(08 Oct 2020) Dexamethasone- effective in improving the P/F ratio in COVID-19 patients

October 9, 2020

Comparison of efficacy of Dexamethasone and Methylprednisolone in improving P/F ratio among COVID-19 patients https://www.medrxiv.org/content/10.1101/2020.10.06.20171579v1 The efficacy of methylprednisolone and dexamethasone in reducing inflammation and improving the partial pressure of arterial oxygen and fraction of inspired oxygen (PaO2/FiO2 or P/F)… Continue reading "(08 Oct 2020) Dexamethasone- effective in improving the P/F ratio in COVID-19 patients"

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