Corticosteroids, Drugs Monitor

(13 Apr 2021) Corticosteroids- patients showed non-significant differences in VFD compared to IL-6R antagonists

April 30, 2021

Clinical Characteristics and Outcomes of Critically ill Mechanically Ventilated COVID-19 Patients Receiving interleukin-6 Receptor Antagonists and/or Corticosteroid Therapy, the INTERACT study: A Multicenter International Observational Study https://www.medrxiv.org/content/10.1101/2021.04.12.21255323v1 NCT04486521- A total of 860 patients met eligibility criteria: 589 received steroids, 170… Continue reading "(13 Apr 2021) Corticosteroids- patients showed non-significant differences in VFD compared to IL-6R antagonists"

(13 Apr 2021) Corticosteroids- no significant effect on the recovery time of anosmia

April 29, 2021

Effect of nasal corticosteroid in the treatment of anosmia due to COVID-19: A randomised double-blind placebo-controlled study https://doi.org/10.1016/j.amjoto.2021.103033 NCT04569825-The study was designed as a randomised, double-blind, placebo-controlled clinical trial. In total, 276 PCR-confirmed COVID-19 patients who were presented to the… Continue reading "(13 Apr 2021) Corticosteroids- no significant effect on the recovery time of anosmia"

(02 Apr 2021) Corticosteroids- not associated with a difference in hospital mortality for patients with OSCI 3-5

April 29, 2021

Effect of corticosteroids on mortality in hospitalized COVID-19 patients not receiving invasive mechanical ventilation https://doi.org/10.1002/cpt.2245 Aim of this observational, single centre, prospective study was to assess the association between corticosteroids and hospital mortality in COVID-19 patients who did not receive… Continue reading "(02 Apr 2021) Corticosteroids- not associated with a difference in hospital mortality for patients with OSCI 3-5"

(16 Mar 2021) Corticosteroids- shorter courses of corticosteroids are associated with an increased risk of being readmitted

April 7, 2021

Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate https://doi.org/10.1016/j.jinf.2021.03.002 196 patients were admitted from the community with a diagnosis of COVID-19 and discharged alive in December 2020. Corticosteroids were prescribed in hospital for… Continue reading "(16 Mar 2021) Corticosteroids- shorter courses of corticosteroids are associated with an increased risk of being readmitted"

(27 Feb 2021) Dexamethasone & Methylprednisolone- mortality was 42% lower in the methylprednisolone group

March 1, 2021

A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients With COVID-19 https://doi.org/10.1177/0885066621994057 A total of 262 patients were grouped as receiving usual care (n = 75), methylprednisolone dosed at least at 1mg/kg/day for >/= 3 days (n = 104),… Continue reading "(27 Feb 2021) Dexamethasone & Methylprednisolone- mortality was 42% lower in the methylprednisolone group"

(23 Feb 2021) Tocilizumab & methylprednisolone- showed significant impact on survival

March 1, 2021

Benefits of early aggressive immunomodulatory therapy (tocilizumab and methylprednisolone) in COVID-19: single center cohort study of 685 patients https://doi.org/10.1016/j.jtauto.2021.100086 From March 3 rd to May 7 th, 685 patients were included for analysis (58.4% males, mean age 68.9 years). Patients… Continue reading "(23 Feb 2021) Tocilizumab & methylprednisolone- showed significant impact on survival"

(11 Feb 2021) Corticosteroids- overall all-cause mortality was significantly lower

February 16, 2021

Safety and Efficacy of Low-Dose Corticosteroids in Patients With Non-severe Coronavirus Disease 2019: A Retrospective Cohort Study https://doi.org/10.7759/cureus.12544 A retrospective cohort study involving 25 patients with a confirmed diagnosis of non-severe COVID-19 infection was conducted. Subjects were assigned to either… Continue reading "(11 Feb 2021) Corticosteroids- overall all-cause mortality was significantly lower"

(29 Jan 2021) Corticosteroids- showed a statistically significant decrease in mortality

February 1, 2021

High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response https://doi.org/10.1371/journal.pone.0243964 HDCPT showed a statistically significant decrease in mortality (HR = 0.087 [95% CI 0.021-0.36]; P < 0.001). 30-day time course analysis of laboratory… Continue reading "(29 Jan 2021) Corticosteroids- showed a statistically significant decrease in mortality"

(25 Jan 2021) Corticosteroids- short-term early use may prolong SARS-CoV 2 shedding

January 28, 2021

Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial https://doi.org/10.1159/000512063 NCT04273321- this trial was terminated early because the number of patients with COVID-19 pneumonia in all the… Continue reading "(25 Jan 2021) Corticosteroids- short-term early use may prolong SARS-CoV 2 shedding"

(06 Jan 2021) Corticosteroids- early use in critically ill patients associated with lower mortality

January 11, 2021

Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study https://doi.org/10.1186/s13054-020-03422-3 This is a nationwide, prospective, multicenter, observational, cohort study in critically ill adult patients with COVID-19 admitted into Intensive Care Units (ICU) in… Continue reading "(06 Jan 2021) Corticosteroids- early use in critically ill patients associated with lower mortality"

Tag: Corticosteroids