Azithromycin, Drugs Monitor

(27 Apr 2021) Azithromycin- adding AZT to SOC did not reduce the risk of hospitalization or death

April 30, 2021

A randomised clinical trial of azithromycin versus standard care in ambulatory COVID-19 – the ATOMIC2 trial https://www.medrxiv.org/content/10.1101/2021.04.21.21255807v1 NCT04381962- 298 participants were enrolled from 3rd June 2020 to 29th January 2021. The primary outcome was assessed in 292 participants. The primary endpoint… Continue reading "(27 Apr 2021) Azithromycin- adding AZT to SOC did not reduce the risk of hospitalization or death"

(26 Feb 2021) Antivirals- dual drug combination produced a significantly rapid PCR conversion rate to negative in three-day treatment

March 1, 2021

A Randomized, Double-Blind, Multicenter Clinical Study Comparing the Efficacy and Safety of a Drug Combination of Lopinavir/Ritonavir-Azithromycin, Lopinavir/Ritonavir-Doxycycline, and Azithromycin-Hydroxychloroquine for Patients Diagnosed with Mild to Moderate COVID-19 Infections https://doi.org/10.1155/2021/6685921 754 subjects participated in this study: 694 patients (92.4%) who… Continue reading "(26 Feb 2021) Antivirals- dual drug combination produced a significantly rapid PCR conversion rate to negative in three-day treatment"

(24 Feb 2021) Hydroxychloroquine & Azithromycin- ineffective in hospitalized patients with mild to moderate COVID-19

March 1, 2021

Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19 https://doi.org/10.1016/j.bjid.2021.101549 The active group comprised 101 (52.3%) patients using hydroxychloroquine associated with azithromycin and the control group 92 (47.7%) patients who did not take these medications. Median age was… Continue reading "(24 Feb 2021) Hydroxychloroquine & Azithromycin- ineffective in hospitalized patients with mild to moderate COVID-19"

(13 Feb 2021) TNR4 therapy- 75% and 81% lower risk of being hospitalized or death

February 16, 2021

Effectiveness of a multidrug therapy consisting of ivermectin, azithromycin, montelukast and acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico https://doi.org/10.1016/j.ijid.2021.02.014 The aim of this study was to assess the effectiveness of a multidrug-therapy consisting… Continue reading "(13 Feb 2021) TNR4 therapy- 75% and 81% lower risk of being hospitalized or death"

(06 Feb 2021) Azithromycin- did not improve survival or other prespecified clinical outcomes

February 16, 2021

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial https://doi.org/10.1016/S0140-6736(21)00149-5 RECOVERY trial-NCT04381936. Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763… Continue reading "(06 Feb 2021) Azithromycin- did not improve survival or other prespecified clinical outcomes"

(01 Dec 2020) Hydroxychloroquine- HCQ+/-AZT does not facilitate virologic cure

December 5, 2020

Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19 https://doi.org/10.1016/j.eclinm.2020.100645 NCT04349592 study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC,… Continue reading "(01 Dec 2020) Hydroxychloroquine- HCQ+/-AZT does not facilitate virologic cure"

(25 Nov 2020) Hydroxychloroquine- combination with AZT helpful in recovery

November 27, 2020

Assessment of COVID-19 Treatment containing both Hydroxychloroquine and Azithromycin: A Natural Clinical Trial https://doi.org/10.1111/ijcp.13856 The study included 161 patients who were admitted with positive RT-PCR and clinical symptoms of COVID-19. In terms of severity, 53 (32.9%) patients had mild condition,… Continue reading "(25 Nov 2020) Hydroxychloroquine- combination with AZT helpful in recovery"

(04 Nov 2020) Azithromycin, Nitazoxanide, Ivermectin and HCQ- AZT in combination with drugs proven beneficial

November 9, 2020

Early COVID-19 Therapy with Azithromycin Plus Nitazoxanide, Ivermectin or Hydroxychloroquine in Outpatient Settings Significantly Reduced Symptoms Compared to Known Outcomes in Untreated Patients https://www.medrxiv.org/content/10.1101/2020.10.31.20223883v1.full.pdf The objective of the present study (NCT04446429) was to elucidate whether the conduction of a full… Continue reading "(04 Nov 2020) Azithromycin, Nitazoxanide, Ivermectin and HCQ- AZT in combination with drugs proven beneficial"

(08 Oct 2020) Hydroxychloroquine, Ivermectin and Azithromycin- no beneficial effects of individual drugs or their combinations

October 9, 2020

Real-World Effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide Healthcare System in Peru https://www.medrxiv.org/content/10.1101/2020.10.06.20208066v2 Among 5683 patients, 200 received HCT, 203 IVM, 1600 AZIT, 692 HCQ… Continue reading "(08 Oct 2020) Hydroxychloroquine, Ivermectin and Azithromycin- no beneficial effects of individual drugs or their combinations"

(07 Sep 2020) Azithromycin- No benefit seen with routine use of azithromycin in combination with hydroxychloroquine in patients with severe COVID-19

September 7, 2020

Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial https://doi.org/10.1016/S0140-6736(20)31862-6 An open-label, randomised clinical trial (NCT04321278) at… Continue reading "(07 Sep 2020) Azithromycin- No benefit seen with routine use of azithromycin in combination with hydroxychloroquine in patients with severe COVID-19"

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