Matched cohort study on the efficacy of tocilizumab in patients with COVID-19 https://doi.org/10.1016/j.onehlt.2021.100214 The objective of this study is to analyze whether the use of tocilizumab is associated with respiratory improvement and a shorter time to discharge in patients with… Continue reading "(12 Jan 2021) Tocilizumab- No clinical benefit associated with the use tocilizumab"
Antiviral drugs in hospitalized patients with COVID-19 – the DisCoVeRy trial https://www.medrxiv.org/content/10.1101/2021.01.08.20248149v1 NCT04315948- An open-label, randomized, adaptive, controlled trial, multi-center trial was conducted with 583 COVID-19 inpatients requiring oxygen and/or ventilatory support from France. Adjusted Odds Ratio (aOR) for the… Continue reading "(09 Jan 2021) Antivirals, DisCovery trial-No improvement of the clinical status at day 15"
Ivermectin as a potential treatment for mild to moderate COVID-19 – A double blind randomized placebo-controlled trial https://www.medrxiv.org/content/10.1101/2021.01.05.21249310v1 CTRI/2020/08/027225- A total of 115 patients were enrolled for the study of which 112 were included in the final analysis. Of them,… Continue reading "(09 Jan 2021) Ivermectin- negative RT-PCR on day 6 of admission with the use of ivermectin"
Combination therapy of IFNbeta1 with lopinavir-ritonavir, increases oxygenation, survival and discharging of sever COVID-19 infected inpatients https://doi.org/10.1016/j.intimp.2020.107329 We conducted a retrospective study of all adult confirmed COVID-19 hospitalized patients who received combination of three doses of 12 million international units… Continue reading "(08 Jan 2021) Interferon beta- associated with decrease in death risks"
Heparin in COVID-19 patients is associated with reduced in-hospital mortality: the multicentre Italian CORIST Study https://doi.org/10.1055/a-1347-6070 In a retrospective observational study, 2,574 unselected patients hospitalised in 30 clinical centres in Italy from February 19, 2020 to May 23, 2020 with… Continue reading "(08 Jan 2021) Heparin-Inhospital heparin treatment was associated with lower mortality"
Compassionate use of Ruxolitinib in patients with SarsCov-2 infection not on mechanical ventilation. Short-term effects on inflammation and ventilation https://doi.org/10.1111/cts.12971 Ruxolitinib was provided as a compassionate use in patients consecutively admitted to our institution for Sars-CoV-2 infection. Inclusion criteria were… Continue reading "(07 Jan 2021) Ruxolitinib- was associated with significant reduction of biomarkers of inflammation"
Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double blind dose response study in Lagos https://www.medrxiv.org/content/10.1101/2021.01.05.21249131v1 ISRCTN40302986- a translational proof of concept (PoC) randomized, double blind placebo controlled, dose response, parallel group study of IV efficacy… Continue reading "(06 Jan 2021) Ivermectin-12 mg IV regime may have superior efficacy"
Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study https://doi.org/10.1186/s13054-020-03422-3 This is a nationwide, prospective, multicenter, observational, cohort study in critically ill adult patients with COVID-19 admitted into Intensive Care Units (ICU) in… Continue reading "(06 Jan 2021) Corticosteroids- early use in critically ill patients associated with lower mortality"
Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study https://doi.org/10.1007/s11739-020-02600-z A retrospective observational cohort study was carried out involving 143 patients with severe COVID-19 pneumonia and moderate… Continue reading "(06 Jan 2021)Anakinra- in combination with TCZ improved prognosis"
The Association of Low Molecular Weight Heparin Use and In-hospital Mortality Among Patients Hospitalized with COVID-19 https://doi.org/10.1007/s10557-020-07133-3 Overall, 525 patients with COVID-19 enrolled with a median age of 64 years (IQR 19), and 49.33% men. Among these, 120 (22.86%) were… Continue reading "(05 Jan 2021) Heparin- LMWH was associated with lower all-cause in-hospital mortality"
