October 2020, Drugs Monitor, Page 3

(01 Oct 2020) Hydroxychloroquine- no clinical benefit of HCQ administered as pre-exposure prophylaxis in hospital-based HCWs

October 5, 2020

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial https://doi.org/10.1001/jamainternmed.2020.6319 This randomized, double-blind, placebo-controlled clinical trial (NCT04329923) was conducted at 2 tertiary urban hospitals, with enrollment from April 9, 2020,… Continue reading "(01 Oct 2020) Hydroxychloroquine- no clinical benefit of HCQ administered as pre-exposure prophylaxis in hospital-based HCWs"

(30 Sep 2020) Hydroxychloroquine- associated with lower mortality

October 5, 2020

The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients https://doi.org/10.1007/s11739-020-02505-x This study investigates the association between the treatment with hydroxychloroquine and mortality in patients admitted with COVID-19. Routinely recorded, clinical data, up to the 24th of April… Continue reading "(30 Sep 2020) Hydroxychloroquine- associated with lower mortality"

(30 Sep 2020) Tocilizumab- effective in COVID-19 patients with severe respiratory impairment receiving NIV

October 5, 2020

Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation https://doi.org/10.1186/s13054-020-03306-6 Out of 79 patients, 41 were treated with TCZ. Twenty-eight patients received intravenous (IV) TCZ and 13 patients received subcutaneous (SC) TCZ. In-hospital overall mortality rate was 38%… Continue reading "(30 Sep 2020) Tocilizumab- effective in COVID-19 patients with severe respiratory impairment receiving NIV"

(30 Sep 2020) Tocilizumab & Corticosteroid- Better outcomes in older patients with severe COVID

October 1, 2020

Combination therapy with tocilizumab and corticosteroids for aged patients with severe COVID-19 pneumonia: a single-center retrospective study https://www.medrxiv.org/content/10.1101/2020.09.26.20202283v1 A retrospective single center study including consecutive patients older than 65 years that developed severe COVID19 between March 3 and May 1,… Continue reading "(30 Sep 2020) Tocilizumab & Corticosteroid- Better outcomes in older patients with severe COVID"

(28 Sep 2020) Corticosteroids- may not be beneficial for patients with mild COVID-19

October 1, 2020

Effect of Corticosteroid Therapy on the Duration of SARS-CoV-2 Clearance in Patients with Mild COVID-19: A Retrospective Cohort Study https://doi.org/10.1007/s40121-020-00337-y Of 82 patients with a mild infection, 40 patients were male (48.8%), with a median age of 49 years (interquartile… Continue reading "(28 Sep 2020) Corticosteroids- may not be beneficial for patients with mild COVID-19"

Month: October 2020

(01 Oct 2020) Hydroxychloroquine- no clinical benefit of HCQ administered as pre-exposure prophylaxis in hospital-based HCWs

(30 Sep 2020) Hydroxychloroquine- associated with lower mortality

(30 Sep 2020) Tocilizumab- effective in COVID-19 patients with severe respiratory impairment receiving NIV

(30 Sep 2020) Tocilizumab & Corticosteroid- Better outcomes in older patients with severe COVID

(28 Sep 2020) Corticosteroids- may not be beneficial for patients with mild COVID-19